CuSO4-Catalyzed Tandem C(sp3)-H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles

Xiang Huan Shan; Mei Mei Wang; Lin Tie; Jian Ping Qu; Yan Biao Kang

doi:10.1021/acs.orglett.9b03751

CuSO₄-Catalyzed Tandem C(sp³)-H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles

Xiang Huan Shan, Mei Mei Wang, Lin Tie, Jian Ping Qu, Yan Biao Kang

School of Chemistry and Moleculai Engineering

University of Science and Technology of China

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A CuSO₄-catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO₄ serves as a low-cost ligand-free redox catalyst. This reaction provides a practical modular synthesis of N-Aryl indoles from isonitriles.

Original language	English
Pages (from-to)	357-360
Number of pages	4
Journal	Organic Letters
Volume	22
Issue number	2
DOIs	https://doi.org/10.1021/acs.orglett.9b03751
State	Published - 17 Jan 2020

Access to Document

10.1021/acs.orglett.9b03751

Cite this

@article{3c1ad35a59eb41dab9918c639dcff6be,

title = "CuSO4-Catalyzed Tandem C(sp3)-H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles",

abstract = "A CuSO4-catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO4 serves as a low-cost ligand-free redox catalyst. This reaction provides a practical modular synthesis of N-Aryl indoles from isonitriles.",

author = "Shan, {Xiang Huan} and Wang, {Mei Mei} and Lin Tie and Qu, {Jian Ping} and Kang, {Yan Biao}",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society.",

year = "2020",

month = jan,

day = "17",

doi = "10.1021/acs.orglett.9b03751",

language = "英语",

volume = "22",

pages = "357--360",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - CuSO4-Catalyzed Tandem C(sp3)-H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles

AU - Shan, Xiang Huan

AU - Wang, Mei Mei

AU - Tie, Lin

AU - Qu, Jian Ping

AU - Kang, Yan Biao

PY - 2020/1/17

Y1 - 2020/1/17

N2 - A CuSO4-catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO4 serves as a low-cost ligand-free redox catalyst. This reaction provides a practical modular synthesis of N-Aryl indoles from isonitriles.

AB - A CuSO4-catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO4 serves as a low-cost ligand-free redox catalyst. This reaction provides a practical modular synthesis of N-Aryl indoles from isonitriles.

UR - http://www.scopus.com/inward/record.url?scp=85078364261&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.9b03751

DO - 10.1021/acs.orglett.9b03751

M3 - 文章

C2 - 31887043

AN - SCOPUS:85078364261

SN - 1523-7060

VL - 22

SP - 357

EP - 360

JO - Organic Letters

JF - Organic Letters

IS - 2

ER -

CuSO₄-Catalyzed Tandem C(sp³)-H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles

Abstract

Access to Document

Other files and links

Fingerprint

Cite this