Dichloroacetophenone Derivatives: A Class of Bioconjugation Reagents for Disulfide Bridging

Liu Hai Wu; Shuguang Zhou; Qun Feng Luo; Jie Sheng Tian; Teck Peng Loh

doi:10.1021/acs.orglett.0c02477

Dichloroacetophenone Derivatives: A Class of Bioconjugation Reagents for Disulfide Bridging

Liu Hai Wu, Shuguang Zhou, Qun Feng Luo, Jie Sheng Tian, Teck Peng Loh

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A mild and biocompatible method for the construction of disulfide bridging in peptides using dichloroacetophenone derivatives is developed. This method is highly selective (chemo, diastereo, regio, etc.) and atom economic and works under biocompatible reaction conditions (metal-free, water, pH 7, rt, etc.).

Original language	English
Pages (from-to)	8193-8197
Number of pages	5
Journal	Organic Letters
Volume	22
Issue number	21
DOIs	https://doi.org/10.1021/acs.orglett.0c02477
State	Published - 6 Nov 2020

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title = "Dichloroacetophenone Derivatives: A Class of Bioconjugation Reagents for Disulfide Bridging",

abstract = "A mild and biocompatible method for the construction of disulfide bridging in peptides using dichloroacetophenone derivatives is developed. This method is highly selective (chemo, diastereo, regio, etc.) and atom economic and works under biocompatible reaction conditions (metal-free, water, pH 7, rt, etc.).",

author = "Wu, {Liu Hai} and Shuguang Zhou and Luo, {Qun Feng} and Tian, {Jie Sheng} and Loh, {Teck Peng}",

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T1 - Dichloroacetophenone Derivatives

T2 - A Class of Bioconjugation Reagents for Disulfide Bridging

AU - Wu, Liu Hai

AU - Zhou, Shuguang

AU - Luo, Qun Feng

AU - Tian, Jie Sheng

AU - Loh, Teck Peng

PY - 2020/11/6

Y1 - 2020/11/6

N2 - A mild and biocompatible method for the construction of disulfide bridging in peptides using dichloroacetophenone derivatives is developed. This method is highly selective (chemo, diastereo, regio, etc.) and atom economic and works under biocompatible reaction conditions (metal-free, water, pH 7, rt, etc.).

AB - A mild and biocompatible method for the construction of disulfide bridging in peptides using dichloroacetophenone derivatives is developed. This method is highly selective (chemo, diastereo, regio, etc.) and atom economic and works under biocompatible reaction conditions (metal-free, water, pH 7, rt, etc.).

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U2 - 10.1021/acs.orglett.0c02477

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SN - 1523-7060

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SP - 8193

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JO - Organic Letters

JF - Organic Letters

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Dichloroacetophenone Derivatives: A Class of Bioconjugation Reagents for Disulfide Bridging

Abstract

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