Abstract
We describe herein a regioselective palladium(II)catalyzed intermolecular hydroarylation of unactivated aliphatic alkenes with electronically and sterically diverse (hetero)arylsilanes under redox-neutral conditions. A removable bidentate 8-amino-quinoline auxiliary was readily employed to dictate the regioselectivity, prevent β-hydride elimination, and facilitate protodepalladation. This silicon-based protocol features a broad substrate scope with excellent functional group compatibility and enables an expeditious route to a variety of γ-aryl butyric acid derivatives in good yields with exclusive anti-Markovnikov selectivity.
Original language | English |
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Pages (from-to) | 9022-9028 |
Number of pages | 7 |
Journal | Organic Letters |
Volume | 22 |
Issue number | 22 |
DOIs | |
State | Published - 20 Nov 2020 |
Externally published | Yes |