Directed palladium(II)-catalyzed intermolecular anti-markovnikov hydroarylation of unactivated alkenes with (hetero)arylsilanes

Ming Zhu Lu, Teck Peng Loh, Haiqing Luo, Zhengsong Hu, Changdong Shao, Yuhe Kan

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

We describe herein a regioselective palladium(II)catalyzed intermolecular hydroarylation of unactivated aliphatic alkenes with electronically and sterically diverse (hetero)arylsilanes under redox-neutral conditions. A removable bidentate 8-amino-quinoline auxiliary was readily employed to dictate the regioselectivity, prevent β-hydride elimination, and facilitate protodepalladation. This silicon-based protocol features a broad substrate scope with excellent functional group compatibility and enables an expeditious route to a variety of γ-aryl butyric acid derivatives in good yields with exclusive anti-Markovnikov selectivity.

Original languageEnglish
Pages (from-to)9022-9028
Number of pages7
JournalOrganic Letters
Volume22
Issue number22
DOIs
StatePublished - 20 Nov 2020
Externally publishedYes

Fingerprint

Dive into the research topics of 'Directed palladium(II)-catalyzed intermolecular anti-markovnikov hydroarylation of unactivated alkenes with (hetero)arylsilanes'. Together they form a unique fingerprint.

Cite this