Dynamic regulation of gut Clostridium-derived short-chain fatty acids

Zhengming Zhu; Liying Zhu; Ling Jiang

doi:10.1016/j.tibtech.2021.10.005

Dynamic regulation of gut Clostridium-derived short-chain fatty acids

Zhengming Zhu, Liying Zhu, Ling Jiang

COLLEGE OF FOOD SCIENCE AND LIGHT INDUSTRY

Nanjing Tech University

Research output: Contribution to journal › Short survey › peer-review

28 Scopus citations

Abstract

Short-chain fatty acids (SCFAs) are major products of intestinal microbial fermentation with beneficial effects for human health. The dynamic balance and real-time monitoring of endogenous SCFA biosynthesis are important for understanding their physiological functions. We discuss the promising future of applying CRISPRi genetic systems and biosensors for targeted SCFA improvement.

Original language	English
Pages (from-to)	266-270
Number of pages	5
Journal	Trends in Biotechnology
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/j.tibtech.2021.10.005
State	Published - Mar 2022

Keywords

CRISPRi genetic system
biosensor
gut Clostridium
short-chain fatty acids
synthetic biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tibtech.2021.10.005

Cite this

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title = "Dynamic regulation of gut Clostridium-derived short-chain fatty acids",

abstract = "Short-chain fatty acids (SCFAs) are major products of intestinal microbial fermentation with beneficial effects for human health. The dynamic balance and real-time monitoring of endogenous SCFA biosynthesis are important for understanding their physiological functions. We discuss the promising future of applying CRISPRi genetic systems and biosensors for targeted SCFA improvement.",

keywords = "CRISPRi genetic system, biosensor, gut Clostridium, short-chain fatty acids, synthetic biology",

author = "Zhengming Zhu and Liying Zhu and Ling Jiang",

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AU - Zhu, Zhengming

AU - Zhu, Liying

AU - Jiang, Ling

PY - 2022/3

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N2 - Short-chain fatty acids (SCFAs) are major products of intestinal microbial fermentation with beneficial effects for human health. The dynamic balance and real-time monitoring of endogenous SCFA biosynthesis are important for understanding their physiological functions. We discuss the promising future of applying CRISPRi genetic systems and biosensors for targeted SCFA improvement.

AB - Short-chain fatty acids (SCFAs) are major products of intestinal microbial fermentation with beneficial effects for human health. The dynamic balance and real-time monitoring of endogenous SCFA biosynthesis are important for understanding their physiological functions. We discuss the promising future of applying CRISPRi genetic systems and biosensors for targeted SCFA improvement.

KW - CRISPRi genetic system

KW - biosensor

KW - gut Clostridium

KW - short-chain fatty acids

KW - synthetic biology

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U2 - 10.1016/j.tibtech.2021.10.005

DO - 10.1016/j.tibtech.2021.10.005

M3 - 短篇评述

C2 - 34716027

AN - SCOPUS:85118262039

SN - 0167-7799

VL - 40

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EP - 270

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 3

ER -

Dynamic regulation of gut Clostridium-derived short-chain fatty acids

Abstract

Keywords

UN SDGs

Access to Document

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