Abstract
An efficient and green electrochemical N-ortho-selective difluoromethylation method of various quinoline and isoquinoline N-oxides has been developed. In this method, sodium difluoromethanesulfinate (HCF2SO2Na) was used as the source of the difluoromethyl moiety, and various N-ortho-selective difluoromethylation quinoline and isoquinoline N-oxides were obtained in good to excellent yields under a constant current. In addition, the reaction was easy to scale up and maintained a good yield. Preliminary mechanism studies suggested that the reaction undergoes a free-radical addition and hydrogen elimination pathway.
Original language | English |
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Pages (from-to) | 1434-1438 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 24 |
Issue number | 7 |
DOIs | |
State | Published - 25 Feb 2022 |