Engineering Niches for Embryonic and Induced Pluripotent Stem Cells

Hongli Mao; Yoshihiro Ito

doi:10.1016/B978-0-12-802734-9.00028-7

Engineering Niches for Embryonic and Induced Pluripotent Stem Cells

Hongli Mao, Yoshihiro Ito

RIKEN

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells have significant potential for use in regenerative medicine because of the ability of these cells to self-renew and differentiate into various types of cells. The fate of ES/iPS cells is dynamically affected by the surrounding environment. Therefore, great efforts have been made to engineer biomimetic niches for ES/iPS cell culture and investigate the effects of environmental stimuli on the fate of ES/iPS cells, as well as to regulate the function of ES/iPS cells for biomedical applications. In this chapter, we focus on the studies describing engineering niches for the maintenance and differentiation of ES/iPS cells.

Original language	English
Title of host publication	Biology and Engineering of Stem Cell Niches
Publisher	Elsevier Inc.
Pages	445-457
Number of pages	13
ISBN (Electronic)	9780128027561
ISBN (Print)	9780128027349
DOIs	https://doi.org/10.1016/B978-0-12-802734-9.00028-7
State	Published - 14 Apr 2017
Externally published	Yes

Keywords

Artificial niche
Differentiation content
Embryonic stem cell
Induced pluripotent stem cell
Pluripotency maintenance

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10.1016/B978-0-12-802734-9.00028-7

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abstract = "Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells have significant potential for use in regenerative medicine because of the ability of these cells to self-renew and differentiate into various types of cells. The fate of ES/iPS cells is dynamically affected by the surrounding environment. Therefore, great efforts have been made to engineer biomimetic niches for ES/iPS cell culture and investigate the effects of environmental stimuli on the fate of ES/iPS cells, as well as to regulate the function of ES/iPS cells for biomedical applications. In this chapter, we focus on the studies describing engineering niches for the maintenance and differentiation of ES/iPS cells.",

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AB - Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells have significant potential for use in regenerative medicine because of the ability of these cells to self-renew and differentiate into various types of cells. The fate of ES/iPS cells is dynamically affected by the surrounding environment. Therefore, great efforts have been made to engineer biomimetic niches for ES/iPS cell culture and investigate the effects of environmental stimuli on the fate of ES/iPS cells, as well as to regulate the function of ES/iPS cells for biomedical applications. In this chapter, we focus on the studies describing engineering niches for the maintenance and differentiation of ES/iPS cells.

KW - Artificial niche

KW - Differentiation content

KW - Embryonic stem cell

KW - Induced pluripotent stem cell

KW - Pluripotency maintenance

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PB - Elsevier Inc.

ER -

Engineering Niches for Embryonic and Induced Pluripotent Stem Cells

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Keywords

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