Fluorescence turn-on detection of hypochlorous acid via HOCl-promoted dihydrofluorescein-ether oxidation and its application in vivo

Yi Zhou; Ju Ying Li; Kai Hui Chu; Ke Liu; Cheng Yao

doi:10.1039/c2cc30265a

Fluorescence turn-on detection of hypochlorous acid via HOCl-promoted dihydrofluorescein-ether oxidation and its application in vivo

Yi Zhou, Ju Ying Li, Kai Hui Chu, Ke Liu, Cheng Yao

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

We report three new water-soluble dihydrofluorescein-ether probes FCN1, FCN2 and FCN3 for the detection of hypochlorous acid (HOCl), which were designed on the basis of a specific HOCl-promoted oxidation reaction. This work also provided a useful method to monitor the accumulated HOCl in specific organelles using a zebrafish model.

Original language	English
Pages (from-to)	4677-4679
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	39
DOIs	https://doi.org/10.1039/c2cc30265a
State	Published - 18 Apr 2012

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abstract = "We report three new water-soluble dihydrofluorescein-ether probes FCN1, FCN2 and FCN3 for the detection of hypochlorous acid (HOCl), which were designed on the basis of a specific HOCl-promoted oxidation reaction. This work also provided a useful method to monitor the accumulated HOCl in specific organelles using a zebrafish model.",

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AU - Zhou, Yi

AU - Li, Ju Ying

AU - Chu, Kai Hui

AU - Liu, Ke

AU - Yao, Cheng

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AB - We report three new water-soluble dihydrofluorescein-ether probes FCN1, FCN2 and FCN3 for the detection of hypochlorous acid (HOCl), which were designed on the basis of a specific HOCl-promoted oxidation reaction. This work also provided a useful method to monitor the accumulated HOCl in specific organelles using a zebrafish model.

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M3 - 文章

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JO - Chemical Communications

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Fluorescence turn-on detection of hypochlorous acid via HOCl-promoted dihydrofluorescein-ether oxidation and its application in vivo

Abstract

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