Fully automated continuous meso-flow synthesis of 5′-nucleotides and deoxynucleotides

Chenjie Zhu; Chenglun Tang; Zhi Cao; Wei He; Yong Chen; Xiaochun Chen; Kai Guo; Hanjie Ying

doi:10.1021/op5002066

Fully automated continuous meso-flow synthesis of 5′-nucleotides and deoxynucleotides

Chenjie Zhu, Chenglun Tang, Zhi Cao, Wei He, Yong Chen, Xiaochun Chen, Kai Guo, Hanjie Ying

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The first continuous meso-flow synthesis of natural and non-natural 5′-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.

Original language	English
Pages (from-to)	1575-1581
Number of pages	7
Journal	Organic Process Research and Development
Volume	18
Issue number	11
DOIs	https://doi.org/10.1021/op5002066
State	Published - 21 Nov 2014

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10.1021/op5002066

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abstract = "The first continuous meso-flow synthesis of natural and non-natural 5′-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.",

author = "Chenjie Zhu and Chenglun Tang and Zhi Cao and Wei He and Yong Chen and Xiaochun Chen and Kai Guo and Hanjie Ying",

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T1 - Fully automated continuous meso-flow synthesis of 5′-nucleotides and deoxynucleotides

AU - Zhu, Chenjie

AU - Tang, Chenglun

AU - Cao, Zhi

AU - He, Wei

AU - Chen, Yong

AU - Chen, Xiaochun

AU - Guo, Kai

AU - Ying, Hanjie

PY - 2014/11/21

Y1 - 2014/11/21

N2 - The first continuous meso-flow synthesis of natural and non-natural 5′-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.

AB - The first continuous meso-flow synthesis of natural and non-natural 5′-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.

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U2 - 10.1021/op5002066

DO - 10.1021/op5002066

M3 - 文章

AN - SCOPUS:84913586863

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SP - 1575

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JO - Organic Process Research and Development

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IS - 11

ER -

Fully automated continuous meso-flow synthesis of 5′-nucleotides and deoxynucleotides

Abstract

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