Genetic manipulation of non-solvent-producing microbial species for effective butanol production

Yang Lv; Yujia Jiang; Wenfang Peng; Yan Fang; Weiliang Dong; Jie Zhou; Wenming Zhang; Fengxue Xin; Min Jiang

doi:10.1002/bbb.2152

Genetic manipulation of non-solvent-producing microbial species for effective butanol production

Yang Lv, Yujia Jiang, Wenfang Peng, Yan Fang, Weiliang Dong, Jie Zhou, Wenming Zhang, Fengxue Xin, Min Jiang

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Butanol is widely used as an important bulk chemical and is a potential biofuel. The depletion of fossil fuels and advances in synthetic biotechnology have led to renewed interest in the biological production of butanol. Solventogenic Clostridium was commonly used to produce butanol through traditional acetone-butanol-ethanol (ABE) fermentation. However, its relatively slow growth rate, low butanol tolerance, and poor production efficiency have hindered the further application of this procedure. Recently, other promising industrial hosts, including Escherichia coli, Saccharomyces cerevisiae, and Clostridium tyrobutyricum, have been studied for potential use in the production of butanol. This review comprehensively summarizes the advantages and challenges of different non-solvent strains for butanol production to identify better the ideal non-solvent hosts for butanol production. Strategies to further increase butanol production are also proposed.

Original language	English
Pages (from-to)	119-130
Number of pages	12
Journal	Biofuels, Bioproducts and Biorefining
Volume	15
Issue number	1
DOIs	https://doi.org/10.1002/bbb.2152
State	Published - 1 Jan 2021

Keywords

ABE fermentation
butanol
genetic engineering
non-solvent-producing host

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/bbb.2152

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title = "Genetic manipulation of non-solvent-producing microbial species for effective butanol production",

abstract = "Butanol is widely used as an important bulk chemical and is a potential biofuel. The depletion of fossil fuels and advances in synthetic biotechnology have led to renewed interest in the biological production of butanol. Solventogenic Clostridium was commonly used to produce butanol through traditional acetone-butanol-ethanol (ABE) fermentation. However, its relatively slow growth rate, low butanol tolerance, and poor production efficiency have hindered the further application of this procedure. Recently, other promising industrial hosts, including Escherichia coli, Saccharomyces cerevisiae, and Clostridium tyrobutyricum, have been studied for potential use in the production of butanol. This review comprehensively summarizes the advantages and challenges of different non-solvent strains for butanol production to identify better the ideal non-solvent hosts for butanol production. Strategies to further increase butanol production are also proposed.",

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author = "Yang Lv and Yujia Jiang and Wenfang Peng and Yan Fang and Weiliang Dong and Jie Zhou and Wenming Zhang and Fengxue Xin and Min Jiang",

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T1 - Genetic manipulation of non-solvent-producing microbial species for effective butanol production

AU - Lv, Yang

AU - Jiang, Yujia

AU - Peng, Wenfang

AU - Fang, Yan

AU - Dong, Weiliang

AU - Zhou, Jie

AU - Zhang, Wenming

AU - Xin, Fengxue

AU - Jiang, Min

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Butanol is widely used as an important bulk chemical and is a potential biofuel. The depletion of fossil fuels and advances in synthetic biotechnology have led to renewed interest in the biological production of butanol. Solventogenic Clostridium was commonly used to produce butanol through traditional acetone-butanol-ethanol (ABE) fermentation. However, its relatively slow growth rate, low butanol tolerance, and poor production efficiency have hindered the further application of this procedure. Recently, other promising industrial hosts, including Escherichia coli, Saccharomyces cerevisiae, and Clostridium tyrobutyricum, have been studied for potential use in the production of butanol. This review comprehensively summarizes the advantages and challenges of different non-solvent strains for butanol production to identify better the ideal non-solvent hosts for butanol production. Strategies to further increase butanol production are also proposed.

AB - Butanol is widely used as an important bulk chemical and is a potential biofuel. The depletion of fossil fuels and advances in synthetic biotechnology have led to renewed interest in the biological production of butanol. Solventogenic Clostridium was commonly used to produce butanol through traditional acetone-butanol-ethanol (ABE) fermentation. However, its relatively slow growth rate, low butanol tolerance, and poor production efficiency have hindered the further application of this procedure. Recently, other promising industrial hosts, including Escherichia coli, Saccharomyces cerevisiae, and Clostridium tyrobutyricum, have been studied for potential use in the production of butanol. This review comprehensively summarizes the advantages and challenges of different non-solvent strains for butanol production to identify better the ideal non-solvent hosts for butanol production. Strategies to further increase butanol production are also proposed.

KW - ABE fermentation

KW - butanol

KW - genetic engineering

KW - non-solvent-producing host

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U2 - 10.1002/bbb.2152

DO - 10.1002/bbb.2152

M3 - 文献综述

AN - SCOPUS:85091376924

SN - 1932-104X

VL - 15

SP - 119

EP - 130

JO - Biofuels, Bioproducts and Biorefining

JF - Biofuels, Bioproducts and Biorefining

IS - 1

ER -

Genetic manipulation of non-solvent-producing microbial species for effective butanol production

Abstract

Keywords

UN SDGs

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