Highly regio- and stereoselective: Trans -iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

Yang Xi; Guohao Zhu; Luning Tang; Shihan Ma; Dongming Zhang; Rong Zhang; Guangke He; Hongjun Zhu

doi:10.1039/c7ob01470h

Highly regio- and stereoselective: Trans -iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

Yang Xi, Guohao Zhu, Luning Tang, Shihan Ma, Dongming Zhang, Rong Zhang, Guangke He, Hongjun Zhu

School of Chemistry and Moleculai Engineering

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A highly regio- and stereoselective trans-iodofluorination reaction of ynamides with NIS and Et₃N·3HF has been achieved, affording (E)-α-fluoro-β-iodoenamides in moderate to good yields. The reaction proceeds under mild reaction conditions and exhibits good functional group compatibility.

Original language	English
Pages (from-to)	7218-7226
Number of pages	9
Journal	Organic and Biomolecular Chemistry
Volume	15
Issue number	34
DOIs	https://doi.org/10.1039/c7ob01470h
State	Published - 2017

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title = "Highly regio- and stereoselective: Trans -iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides",

abstract = "A highly regio- and stereoselective trans-iodofluorination reaction of ynamides with NIS and Et3N·3HF has been achieved, affording (E)-α-fluoro-β-iodoenamides in moderate to good yields. The reaction proceeds under mild reaction conditions and exhibits good functional group compatibility.",

author = "Yang Xi and Guohao Zhu and Luning Tang and Shihan Ma and Dongming Zhang and Rong Zhang and Guangke He and Hongjun Zhu",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2017.",

year = "2017",

doi = "10.1039/c7ob01470h",

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T1 - Highly regio- and stereoselective

T2 - Trans -iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

AU - Xi, Yang

AU - Zhu, Guohao

AU - Tang, Luning

AU - Ma, Shihan

AU - Zhang, Dongming

AU - Zhang, Rong

AU - He, Guangke

AU - Zhu, Hongjun

PY - 2017

Y1 - 2017

N2 - A highly regio- and stereoselective trans-iodofluorination reaction of ynamides with NIS and Et3N·3HF has been achieved, affording (E)-α-fluoro-β-iodoenamides in moderate to good yields. The reaction proceeds under mild reaction conditions and exhibits good functional group compatibility.

AB - A highly regio- and stereoselective trans-iodofluorination reaction of ynamides with NIS and Et3N·3HF has been achieved, affording (E)-α-fluoro-β-iodoenamides in moderate to good yields. The reaction proceeds under mild reaction conditions and exhibits good functional group compatibility.

UR - http://www.scopus.com/inward/record.url?scp=85028584919&partnerID=8YFLogxK

U2 - 10.1039/c7ob01470h

DO - 10.1039/c7ob01470h

M3 - 文章

C2 - 28816329

AN - SCOPUS:85028584919

SN - 1477-0520

VL - 15

SP - 7218

EP - 7226

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 34

ER -

Highly regio- and stereoselective: Trans -iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

Abstract

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