Highly sensitive "signal-on" electrochemiluminescent biosensor for the detection of DNA based on dual quenching and strand displacement reaction

Jing Lou; Zhaoyin Wang; Xiao Wang; Jianchun Bao; Wenwen Tu; Zhihui Dai

doi:10.1039/c5cc06156c

Highly sensitive "signal-on" electrochemiluminescent biosensor for the detection of DNA based on dual quenching and strand displacement reaction

Jing Lou, Zhaoyin Wang, Xiao Wang, Jianchun Bao, Wenwen Tu, Zhihui Dai

Nanjing Normal University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A "signal-on" electrochemiluminescent DNA biosensing platform was proposed based on the dual quenching and strand displacement reaction. This novel "signal-on" detection strategy revealed its sensitivity in achieving a detection limit of 2.4 aM and its selectivity in distinguishing single nucleotide polymorphism of target DNA.

Original language	English
Pages (from-to)	14578-14581
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	78
DOIs	https://doi.org/10.1039/c5cc06156c
State	Published - 10 Aug 2015
Externally published	Yes

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10.1039/c5cc06156c

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author = "Jing Lou and Zhaoyin Wang and Xiao Wang and Jianchun Bao and Wenwen Tu and Zhihui Dai",

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T1 - Highly sensitive "signal-on" electrochemiluminescent biosensor for the detection of DNA based on dual quenching and strand displacement reaction

AU - Lou, Jing

AU - Wang, Zhaoyin

AU - Wang, Xiao

AU - Bao, Jianchun

AU - Tu, Wenwen

AU - Dai, Zhihui

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015/8/10

Y1 - 2015/8/10

N2 - A "signal-on" electrochemiluminescent DNA biosensing platform was proposed based on the dual quenching and strand displacement reaction. This novel "signal-on" detection strategy revealed its sensitivity in achieving a detection limit of 2.4 aM and its selectivity in distinguishing single nucleotide polymorphism of target DNA.

AB - A "signal-on" electrochemiluminescent DNA biosensing platform was proposed based on the dual quenching and strand displacement reaction. This novel "signal-on" detection strategy revealed its sensitivity in achieving a detection limit of 2.4 aM and its selectivity in distinguishing single nucleotide polymorphism of target DNA.

UR - http://www.scopus.com/inward/record.url?scp=84941892606&partnerID=8YFLogxK

U2 - 10.1039/c5cc06156c

DO - 10.1039/c5cc06156c

M3 - 文章

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AN - SCOPUS:84941892606

SN - 1359-7345

VL - 51

SP - 14578

EP - 14581

JO - Chemical Communications

JF - Chemical Communications

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ER -

Highly sensitive "signal-on" electrochemiluminescent biosensor for the detection of DNA based on dual quenching and strand displacement reaction

Abstract

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