TY - JOUR
T1 - Improved negative charge of tight ceramic ultrafiltration membranes for protein-resistant and easy-cleaning performance
AU - Ye, Yahan
AU - Han, Qing
AU - Zhao, Chen
AU - Ke, Wei
AU - Qiu, Minghui
AU - Chen, Xianfu
AU - Fan, Yiqun
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/3/15
Y1 - 2023/3/15
N2 - Fouling caused by adsorption is a challenge in protein separation and purification using membrane technology. The interaction between the membrane surface and proteins is significant for developing antifouling modified membranes. In this study, a negative ZrO2 tubular ceramic membrane was constructed by grafting polyacrylic acid (PAA) to mitigate protein fouling. PAA of 2000 Da had little effect on the membrane pore and surface wettability, as characterized by XPS, dextran retention, contact angle, and water permeance. The protein resistance of the modified membrane was investigated by protein filtration. The modified membranes had a higher stable normalized flux (0.6) and flux recovery ratio (90 %) than that of the original membrane. In addition, the performance of the modified membranes was sensitive to the pore sizes of the original membranes. When the original membrane was unable to completely reject bovine serum albumin (BSA), the weak interaction between BSA and the membrane pores would reduce rejection after PAA modification. And the flux recovery ratio of modified membrane increased by 55 %. Overall, PAA modification reduces irreversible fouling by electrostatic repulsion, and improves the protein-resistant and easy-cleaning performance of ceramic membranes.
AB - Fouling caused by adsorption is a challenge in protein separation and purification using membrane technology. The interaction between the membrane surface and proteins is significant for developing antifouling modified membranes. In this study, a negative ZrO2 tubular ceramic membrane was constructed by grafting polyacrylic acid (PAA) to mitigate protein fouling. PAA of 2000 Da had little effect on the membrane pore and surface wettability, as characterized by XPS, dextran retention, contact angle, and water permeance. The protein resistance of the modified membrane was investigated by protein filtration. The modified membranes had a higher stable normalized flux (0.6) and flux recovery ratio (90 %) than that of the original membrane. In addition, the performance of the modified membranes was sensitive to the pore sizes of the original membranes. When the original membrane was unable to completely reject bovine serum albumin (BSA), the weak interaction between BSA and the membrane pores would reduce rejection after PAA modification. And the flux recovery ratio of modified membrane increased by 55 %. Overall, PAA modification reduces irreversible fouling by electrostatic repulsion, and improves the protein-resistant and easy-cleaning performance of ceramic membranes.
KW - Ceramic membrane
KW - Polyacrylic acid
KW - Protein resistance
KW - Surface modification
KW - Tight ultrafiltration membranes
UR - http://www.scopus.com/inward/record.url?scp=85145851306&partnerID=8YFLogxK
U2 - 10.1016/j.seppur.2022.123082
DO - 10.1016/j.seppur.2022.123082
M3 - 文章
AN - SCOPUS:85145851306
SN - 1383-5866
VL - 309
JO - Separation and Purification Technology
JF - Separation and Purification Technology
M1 - 123082
ER -