In vivo behaviors of Ca(OH)2 activated nano SiO2 (nCa/nSi = 3) cement in rabbit model

Qing Lin; Xiaojuan Zhang; Chunhua Lu; Xianghui Lan; Guihua Hou; Zhongzi Xu

doi:10.1016/j.msec.2015.09.032

In vivo behaviors of Ca(OH)₂ activated nano SiO₂ (n_Ca/n_Si = 3) cement in rabbit model

Qing Lin, Xiaojuan Zhang, Chunhua Lu, Xianghui Lan, Guihua Hou, Zhongzi Xu

College of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

In vivo behaviors of Ca(OH)₂ activated nano SiO₂ (n_Ca/n_Si = 3, TCS) cement were investigated in the rabbit femoral defects using the poly(methyl methacrylate) (PMMA) as control. The deposited apatite and CaCO₃ layers round TCS paste surfaces were completely used to construct the new bone tissue. TCS paste could stimulate the formation of new bone tissue in marrow tissue. The osteostimulation was mainly attributed to the proliferation and differentiation effects of Ca and Si ions released from TCS paste on the osteoprogenitor cells. However, Calcium-Silicate-Hydrate (C-S-H) gel in TCS paste was harder to degradate than Ca(OH)₂. TCS paste kept the original shape during implantation, and could not provide the pores or spaces for further formation of bone tissue. Osteolytic defects induced by wear particles from TCS paste surface could not be completely avoided, because of the interfacial strain and the extensive micromotion between TCS paste surface and new bone tissue. Overall, our results indicated that Ca(OH)₂ activated nano SiO₂ cement was bioactivity and osteostimulation. The further improvements of Ca(OH)₂ activated nano SiO₂ cement should be done by achieving a balance between biological properties and mechanical performances.

Original language	English
Article number	5744
Pages (from-to)	774-781
Number of pages	8
Journal	Materials Science and Engineering C
Volume	58
DOIs	https://doi.org/10.1016/j.msec.2015.09.032
State	Published - 1 Jan 2016

Keywords

Biocompatibility
Bone cement
Nano SiO
Osteostimulation

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title = "In vivo behaviors of Ca(OH)2 activated nano SiO2 (nCa/nSi = 3) cement in rabbit model",

abstract = "In vivo behaviors of Ca(OH)2 activated nano SiO2 (nCa/nSi = 3, TCS) cement were investigated in the rabbit femoral defects using the poly(methyl methacrylate) (PMMA) as control. The deposited apatite and CaCO3 layers round TCS paste surfaces were completely used to construct the new bone tissue. TCS paste could stimulate the formation of new bone tissue in marrow tissue. The osteostimulation was mainly attributed to the proliferation and differentiation effects of Ca and Si ions released from TCS paste on the osteoprogenitor cells. However, Calcium-Silicate-Hydrate (C-S-H) gel in TCS paste was harder to degradate than Ca(OH)2. TCS paste kept the original shape during implantation, and could not provide the pores or spaces for further formation of bone tissue. Osteolytic defects induced by wear particles from TCS paste surface could not be completely avoided, because of the interfacial strain and the extensive micromotion between TCS paste surface and new bone tissue. Overall, our results indicated that Ca(OH)2 activated nano SiO2 cement was bioactivity and osteostimulation. The further improvements of Ca(OH)2 activated nano SiO2 cement should be done by achieving a balance between biological properties and mechanical performances.",

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author = "Qing Lin and Xiaojuan Zhang and Chunhua Lu and Xianghui Lan and Guihua Hou and Zhongzi Xu",

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doi = "10.1016/j.msec.2015.09.032",

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T1 - In vivo behaviors of Ca(OH)2 activated nano SiO2 (nCa/nSi = 3) cement in rabbit model

AU - Lin, Qing

AU - Zhang, Xiaojuan

AU - Lu, Chunhua

AU - Lan, Xianghui

AU - Hou, Guihua

AU - Xu, Zhongzi

PY - 2016/1/1

Y1 - 2016/1/1

N2 - In vivo behaviors of Ca(OH)2 activated nano SiO2 (nCa/nSi = 3, TCS) cement were investigated in the rabbit femoral defects using the poly(methyl methacrylate) (PMMA) as control. The deposited apatite and CaCO3 layers round TCS paste surfaces were completely used to construct the new bone tissue. TCS paste could stimulate the formation of new bone tissue in marrow tissue. The osteostimulation was mainly attributed to the proliferation and differentiation effects of Ca and Si ions released from TCS paste on the osteoprogenitor cells. However, Calcium-Silicate-Hydrate (C-S-H) gel in TCS paste was harder to degradate than Ca(OH)2. TCS paste kept the original shape during implantation, and could not provide the pores or spaces for further formation of bone tissue. Osteolytic defects induced by wear particles from TCS paste surface could not be completely avoided, because of the interfacial strain and the extensive micromotion between TCS paste surface and new bone tissue. Overall, our results indicated that Ca(OH)2 activated nano SiO2 cement was bioactivity and osteostimulation. The further improvements of Ca(OH)2 activated nano SiO2 cement should be done by achieving a balance between biological properties and mechanical performances.

AB - In vivo behaviors of Ca(OH)2 activated nano SiO2 (nCa/nSi = 3, TCS) cement were investigated in the rabbit femoral defects using the poly(methyl methacrylate) (PMMA) as control. The deposited apatite and CaCO3 layers round TCS paste surfaces were completely used to construct the new bone tissue. TCS paste could stimulate the formation of new bone tissue in marrow tissue. The osteostimulation was mainly attributed to the proliferation and differentiation effects of Ca and Si ions released from TCS paste on the osteoprogenitor cells. However, Calcium-Silicate-Hydrate (C-S-H) gel in TCS paste was harder to degradate than Ca(OH)2. TCS paste kept the original shape during implantation, and could not provide the pores or spaces for further formation of bone tissue. Osteolytic defects induced by wear particles from TCS paste surface could not be completely avoided, because of the interfacial strain and the extensive micromotion between TCS paste surface and new bone tissue. Overall, our results indicated that Ca(OH)2 activated nano SiO2 cement was bioactivity and osteostimulation. The further improvements of Ca(OH)2 activated nano SiO2 cement should be done by achieving a balance between biological properties and mechanical performances.

KW - Biocompatibility

KW - Bone cement

KW - Nano SiO

KW - Osteostimulation

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In vivo behaviors of Ca(OH)₂ activated nano SiO₂ (n_Ca/n_Si = 3) cement in rabbit model

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