In(III)-pybox complex catalyzed enantioselective Mukaiyama aldol reactions between polymeric or hydrated glyoxylates and enolsilanes derived from aryl ketones

A highly efficient In(III)-pybox complex catalyzed enantio-selective Mukaiyama aldol reaction between polymeric or hydrated glyoxylates and enolsilanes derived from aryl ketones is described. Excellent enantioselectivities, diastereoselectivities and yields were obtained with a broad substrate scope. The mild reaction conditions and simple operation make this methodology very practical.