Iodine-mediated oxidation of ynamides: A facile access to N-monosubstituted α-ketoamides and α-ketoimides

Hai Huang; Guangke He; Xiaolin Zhu; Xiaodong Jin; Shineng Qiu; Hongjun Zhu

doi:10.1002/ejoc.201402538

Iodine-mediated oxidation of ynamides: A facile access to N-monosubstituted α-ketoamides and α-ketoimides

Hai Huang, Guangke He, Xiaolin Zhu, Xiaodong Jin, Shineng Qiu, Hongjun Zhu

School of Chemistry and Moleculai Engineering

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

An efficient iodine-mediated oxidation reaction for ynamides has been developed to produce N-monosubstituted α-ketoamides and α-ketoimides. This oxidative method, which exhibits good functional group tolerance, was performed under mild conditions without a metal catalyst.

Original language	English
Pages (from-to)	7174-7183
Number of pages	10
Journal	European Journal of Organic Chemistry
Volume	2014
Issue number	32
DOIs	https://doi.org/10.1002/ejoc.201402538
State	Published - Nov 2014

Keywords

Alkynes
Amides
Iodine
Oxidation
Synthetic methods

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10.1002/ejoc.201402538

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abstract = "An efficient iodine-mediated oxidation reaction for ynamides has been developed to produce N-monosubstituted α-ketoamides and α-ketoimides. This oxidative method, which exhibits good functional group tolerance, was performed under mild conditions without a metal catalyst.",

keywords = "Alkynes, Amides, Iodine, Oxidation, Synthetic methods",

author = "Hai Huang and Guangke He and Xiaolin Zhu and Xiaodong Jin and Shineng Qiu and Hongjun Zhu",

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T2 - A facile access to N-monosubstituted α-ketoamides and α-ketoimides

AU - Huang, Hai

AU - He, Guangke

AU - Zhu, Xiaolin

AU - Jin, Xiaodong

AU - Qiu, Shineng

AU - Zhu, Hongjun

PY - 2014/11

Y1 - 2014/11

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AB - An efficient iodine-mediated oxidation reaction for ynamides has been developed to produce N-monosubstituted α-ketoamides and α-ketoimides. This oxidative method, which exhibits good functional group tolerance, was performed under mild conditions without a metal catalyst.

KW - Alkynes

KW - Amides

KW - Iodine

KW - Oxidation

KW - Synthetic methods

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DO - 10.1002/ejoc.201402538

M3 - 文章

AN - SCOPUS:84919363392

SN - 1434-193X

VL - 2014

SP - 7174

EP - 7183

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 32

ER -

Iodine-mediated oxidation of ynamides: A facile access to N-monosubstituted α-ketoamides and α-ketoimides

Abstract

Keywords

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