Iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates toward 2,4,6-trisubstituted pyrimidines

Qinghuan Wu; Luchao Li; Binyan Xu; Jie Sun; Dong Ji; Yuguang Li; Lei Shen; Zheng Fang; Jindian Duan; Beining Chen; Kai Guo

doi:10.1016/j.gresc.2023.01.001

Iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates toward 2,4,6-trisubstituted pyrimidines

Qinghuan Wu, Luchao Li, Binyan Xu, Jie Sun, Dong Ji, Yuguang Li, Lei Shen, Zheng Fang, Jindian Duan, Beining Chen, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

An iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates is described. This strategy employs amidines as CN units and provides a new protocol for the construction of 2,4,6-trisubstituted pyrimidines under batch and continuous flow conditions in moderate to good yields, exhibiting good functional group tolerance, scalability and operational simplicity.

Original language	English
Pages (from-to)	150-153
Number of pages	4
Journal	Green Synthesis and Catalysis
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.gresc.2023.01.001
State	Published - May 2023

Keywords

Amidines
Annulation
Iron
Ketoxime acetates
Pyrimidines

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10.1016/j.gresc.2023.01.001

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title = "Iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates toward 2,4,6-trisubstituted pyrimidines",

abstract = "An iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates is described. This strategy employs amidines as CN units and provides a new protocol for the construction of 2,4,6-trisubstituted pyrimidines under batch and continuous flow conditions in moderate to good yields, exhibiting good functional group tolerance, scalability and operational simplicity.",

keywords = "Amidines, Annulation, Iron, Ketoxime acetates, Pyrimidines",

author = "Qinghuan Wu and Luchao Li and Binyan Xu and Jie Sun and Dong Ji and Yuguang Li and Lei Shen and Zheng Fang and Jindian Duan and Beining Chen and Kai Guo",

note = "Publisher Copyright: {\textcopyright} 2023 Fudan University",

year = "2023",

month = may,

doi = "10.1016/j.gresc.2023.01.001",

language = "英语",

volume = "4",

pages = "150--153",

journal = "Green Synthesis and Catalysis",

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TY - JOUR

T1 - Iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates toward 2,4,6-trisubstituted pyrimidines

AU - Wu, Qinghuan

AU - Li, Luchao

AU - Xu, Binyan

AU - Sun, Jie

AU - Ji, Dong

AU - Li, Yuguang

AU - Shen, Lei

AU - Fang, Zheng

AU - Duan, Jindian

AU - Chen, Beining

AU - Guo, Kai

PY - 2023/5

Y1 - 2023/5

N2 - An iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates is described. This strategy employs amidines as CN units and provides a new protocol for the construction of 2,4,6-trisubstituted pyrimidines under batch and continuous flow conditions in moderate to good yields, exhibiting good functional group tolerance, scalability and operational simplicity.

AB - An iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates is described. This strategy employs amidines as CN units and provides a new protocol for the construction of 2,4,6-trisubstituted pyrimidines under batch and continuous flow conditions in moderate to good yields, exhibiting good functional group tolerance, scalability and operational simplicity.

KW - Amidines

KW - Annulation

KW - Iron

KW - Ketoxime acetates

KW - Pyrimidines

UR - http://www.scopus.com/inward/record.url?scp=85148713951&partnerID=8YFLogxK

U2 - 10.1016/j.gresc.2023.01.001

DO - 10.1016/j.gresc.2023.01.001

M3 - 文章

AN - SCOPUS:85148713951

SN - 2666-5549

VL - 4

SP - 150

EP - 153

JO - Green Synthesis and Catalysis

JF - Green Synthesis and Catalysis

IS - 2

ER -

Iron-catalyzed [4 + 2] annulation of amidines with α,β-unsaturated ketoxime acetates toward 2,4,6-trisubstituted pyrimidines

Abstract

Keywords

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