Ligand Promoted Pd-Catalyzed High para-Selective C-H Olefination

Shuo Jie Shen; Yao Dong Li; Ye Ge; Xu Yang; Lin Hu Li; Hua Jin Xu; Yi Hu

doi:10.1021/acs.orglett.3c03201

Ligand Promoted Pd-Catalyzed High para-Selective C-H Olefination

Shuo Jie Shen, Yao Dong Li, Ye Ge, Xu Yang, Lin Hu Li, Hua Jin Xu, Yi Hu

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Achieving high para-selective C-H functionalized products of benzoic acid derivatives using a designed template is still a daunting challenge because the carbonyl group also could coordinate with metal to activate the ortho-C-H bond. Herein, we report the ligand promoted high para-selective C-H olefination of benzoic acid derivatives; we screened a series of ligands increasing the ratio of p:others from 62:38 to 96:4. This work may find application in the construction of para-substituted benzoic acid derivatives.

Original language	English
Pages (from-to)	9092-9096
Number of pages	5
Journal	Organic Letters
Volume	25
Issue number	51
DOIs	https://doi.org/10.1021/acs.orglett.3c03201
State	Published - 29 Dec 2023

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title = "Ligand Promoted Pd-Catalyzed High para-Selective C-H Olefination",

abstract = "Achieving high para-selective C-H functionalized products of benzoic acid derivatives using a designed template is still a daunting challenge because the carbonyl group also could coordinate with metal to activate the ortho-C-H bond. Herein, we report the ligand promoted high para-selective C-H olefination of benzoic acid derivatives; we screened a series of ligands increasing the ratio of p:others from 62:38 to 96:4. This work may find application in the construction of para-substituted benzoic acid derivatives.",

author = "Shen, {Shuo Jie} and Li, {Yao Dong} and Ye Ge and Xu Yang and Li, {Lin Hu} and Xu, {Hua Jin} and Yi Hu",

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doi = "10.1021/acs.orglett.3c03201",

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T1 - Ligand Promoted Pd-Catalyzed High para-Selective C-H Olefination

AU - Shen, Shuo Jie

AU - Li, Yao Dong

AU - Ge, Ye

AU - Yang, Xu

AU - Li, Lin Hu

AU - Xu, Hua Jin

AU - Hu, Yi

PY - 2023/12/29

Y1 - 2023/12/29

N2 - Achieving high para-selective C-H functionalized products of benzoic acid derivatives using a designed template is still a daunting challenge because the carbonyl group also could coordinate with metal to activate the ortho-C-H bond. Herein, we report the ligand promoted high para-selective C-H olefination of benzoic acid derivatives; we screened a series of ligands increasing the ratio of p:others from 62:38 to 96:4. This work may find application in the construction of para-substituted benzoic acid derivatives.

AB - Achieving high para-selective C-H functionalized products of benzoic acid derivatives using a designed template is still a daunting challenge because the carbonyl group also could coordinate with metal to activate the ortho-C-H bond. Herein, we report the ligand promoted high para-selective C-H olefination of benzoic acid derivatives; we screened a series of ligands increasing the ratio of p:others from 62:38 to 96:4. This work may find application in the construction of para-substituted benzoic acid derivatives.

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U2 - 10.1021/acs.orglett.3c03201

DO - 10.1021/acs.orglett.3c03201

M3 - 文章

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AN - SCOPUS:85180987050

SN - 1523-7060

VL - 25

SP - 9092

EP - 9096

JO - Organic Letters

JF - Organic Letters

IS - 51

ER -

Ligand Promoted Pd-Catalyzed High para-Selective C-H Olefination

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