Luminescent supramolecular polymer nanoparticles for ratiometric hypoxia sensing, imaging and therapy

Yuan Yuan Huang; Ye Tian; Xiao Qin Liu; Zhongwei Niu; Qing Zheng Yang; Vaidhyanathan Ramamurthy; Chen Ho Tung; Yu Zhe Chen; Li Zhu Wu

doi:10.1039/c8qm00309b

Luminescent supramolecular polymer nanoparticles for ratiometric hypoxia sensing, imaging and therapy

Yuan Yuan Huang, Ye Tian, Xiao Qin Liu, Zhongwei Niu, Qing Zheng Yang, Vaidhyanathan Ramamurthy, Chen Ho Tung, Yu Zhe Chen, Li Zhu Wu

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Hydrogen-bonded supramolecular polymer nanoparticles (SPNPs), serving as a ratiometric oxygen nanoprobe for hypoxia sensing and photodynamic therapy (PDT) treatment, were designed. Herein, oxygen-sensitive phosphorescent Pt(ii) porphyrin moiety and oxygen-insensitive fluorescent 9,10-diphenylanthracene moiety were assembled through quadruple hydrogen bonding into SPNPs. The efficient energy transfer between the monomeric donor-acceptor pairs in the SPNPs leads to enhanced phosphorescence with long lifetimes. The resulting bright phosphorescence can realize hypoxia sensing in living cells and generate singlet oxygen efficiently in SPNPs to kill cancer cells. This is the first example of a multi-functional supramolecular polymer-based nanoprobe for ratiometric hypoxia sensing, imaging and PDT treatment.

Original language	English
Pages (from-to)	1893-1899
Number of pages	7
Journal	Materials Chemistry Frontiers
Volume	2
Issue number	10
DOIs	https://doi.org/10.1039/c8qm00309b
State	Published - Oct 2018
Externally published	Yes

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title = "Luminescent supramolecular polymer nanoparticles for ratiometric hypoxia sensing, imaging and therapy",

abstract = "Hydrogen-bonded supramolecular polymer nanoparticles (SPNPs), serving as a ratiometric oxygen nanoprobe for hypoxia sensing and photodynamic therapy (PDT) treatment, were designed. Herein, oxygen-sensitive phosphorescent Pt(ii) porphyrin moiety and oxygen-insensitive fluorescent 9,10-diphenylanthracene moiety were assembled through quadruple hydrogen bonding into SPNPs. The efficient energy transfer between the monomeric donor-acceptor pairs in the SPNPs leads to enhanced phosphorescence with long lifetimes. The resulting bright phosphorescence can realize hypoxia sensing in living cells and generate singlet oxygen efficiently in SPNPs to kill cancer cells. This is the first example of a multi-functional supramolecular polymer-based nanoprobe for ratiometric hypoxia sensing, imaging and PDT treatment.",

author = "Huang, {Yuan Yuan} and Ye Tian and Liu, {Xiao Qin} and Zhongwei Niu and Yang, {Qing Zheng} and Vaidhyanathan Ramamurthy and Tung, {Chen Ho} and Chen, {Yu Zhe} and Wu, {Li Zhu}",

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doi = "10.1039/c8qm00309b",

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T1 - Luminescent supramolecular polymer nanoparticles for ratiometric hypoxia sensing, imaging and therapy

AU - Huang, Yuan Yuan

AU - Tian, Ye

AU - Liu, Xiao Qin

AU - Niu, Zhongwei

AU - Yang, Qing Zheng

AU - Ramamurthy, Vaidhyanathan

AU - Tung, Chen Ho

AU - Chen, Yu Zhe

AU - Wu, Li Zhu

PY - 2018/10

Y1 - 2018/10

N2 - Hydrogen-bonded supramolecular polymer nanoparticles (SPNPs), serving as a ratiometric oxygen nanoprobe for hypoxia sensing and photodynamic therapy (PDT) treatment, were designed. Herein, oxygen-sensitive phosphorescent Pt(ii) porphyrin moiety and oxygen-insensitive fluorescent 9,10-diphenylanthracene moiety were assembled through quadruple hydrogen bonding into SPNPs. The efficient energy transfer between the monomeric donor-acceptor pairs in the SPNPs leads to enhanced phosphorescence with long lifetimes. The resulting bright phosphorescence can realize hypoxia sensing in living cells and generate singlet oxygen efficiently in SPNPs to kill cancer cells. This is the first example of a multi-functional supramolecular polymer-based nanoprobe for ratiometric hypoxia sensing, imaging and PDT treatment.

AB - Hydrogen-bonded supramolecular polymer nanoparticles (SPNPs), serving as a ratiometric oxygen nanoprobe for hypoxia sensing and photodynamic therapy (PDT) treatment, were designed. Herein, oxygen-sensitive phosphorescent Pt(ii) porphyrin moiety and oxygen-insensitive fluorescent 9,10-diphenylanthracene moiety were assembled through quadruple hydrogen bonding into SPNPs. The efficient energy transfer between the monomeric donor-acceptor pairs in the SPNPs leads to enhanced phosphorescence with long lifetimes. The resulting bright phosphorescence can realize hypoxia sensing in living cells and generate singlet oxygen efficiently in SPNPs to kill cancer cells. This is the first example of a multi-functional supramolecular polymer-based nanoprobe for ratiometric hypoxia sensing, imaging and PDT treatment.

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DO - 10.1039/c8qm00309b

M3 - 文章

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JO - Materials Chemistry Frontiers

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Luminescent supramolecular polymer nanoparticles for ratiometric hypoxia sensing, imaging and therapy

Abstract

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