Metal-free hydration of ynamides: Convenient approach to amides

Hai Huang; Luning Tang; Yang Xi; Guangke He; Hongjun Zhu

doi:10.1016/j.tetlet.2016.03.052

Metal-free hydration of ynamides: Convenient approach to amides

Hai Huang, Luning Tang, Yang Xi, Guangke He, Hongjun Zhu

School of Chemistry and Moleculai Engineering

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The trifluoroacetic acid (TFA) mediated hydration of ynamides was developed, which is an efficient approach for the synthesis of N-monosubstituted amides. This convenient method is effective with a wide range of substrates under room temperature condition, and the products are obtained in high to excellent yields through an easy work-up process.

Original language	English
Pages (from-to)	1873-1876
Number of pages	4
Journal	Tetrahedron Letters
Volume	57
Issue number	17
DOIs	https://doi.org/10.1016/j.tetlet.2016.03.052
State	Published - 27 Apr 2016

Keywords

Amide bond
Hydration
Metal-free
Room temperature
Ynamides

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abstract = "The trifluoroacetic acid (TFA) mediated hydration of ynamides was developed, which is an efficient approach for the synthesis of N-monosubstituted amides. This convenient method is effective with a wide range of substrates under room temperature condition, and the products are obtained in high to excellent yields through an easy work-up process.",

keywords = "Amide bond, Hydration, Metal-free, Room temperature, Ynamides",

author = "Hai Huang and Luning Tang and Yang Xi and Guangke He and Hongjun Zhu",

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T2 - Convenient approach to amides

AU - Huang, Hai

AU - Tang, Luning

AU - Xi, Yang

AU - He, Guangke

AU - Zhu, Hongjun

PY - 2016/4/27

Y1 - 2016/4/27

N2 - The trifluoroacetic acid (TFA) mediated hydration of ynamides was developed, which is an efficient approach for the synthesis of N-monosubstituted amides. This convenient method is effective with a wide range of substrates under room temperature condition, and the products are obtained in high to excellent yields through an easy work-up process.

AB - The trifluoroacetic acid (TFA) mediated hydration of ynamides was developed, which is an efficient approach for the synthesis of N-monosubstituted amides. This convenient method is effective with a wide range of substrates under room temperature condition, and the products are obtained in high to excellent yields through an easy work-up process.

KW - Amide bond

KW - Hydration

KW - Metal-free

KW - Room temperature

KW - Ynamides

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M3 - 文章

AN - SCOPUS:84961768890

SN - 0040-4039

VL - 57

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EP - 1876

JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

Metal-free hydration of ynamides: Convenient approach to amides

Abstract

Keywords

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