Metal-free oxidative esterification of acetophenones with alcohols: A facile one-pot approach to α-ketoesters

Shiyu Guo; Zhongxue Dai; Zhao Yang; Ning Zhu; Li Wan; Xin Li; Chengkou Liu; Zheng Fang; Kai Guo

doi:10.1039/c6ra19485k

Metal-free oxidative esterification of acetophenones with alcohols: A facile one-pot approach to α-ketoesters

Shiyu Guo, Zhongxue Dai, Zhao Yang, Ning Zhu, Li Wan, Xin Li, Chengkou Liu, Zheng Fang, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

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Abstract

A novel and efficient oxidative esterification method for the synthesis of α-ketoesters has been developed under mild and environmentally benign conditions, which is a facile one-pot approach to α-ketoesters from commercially available acetophenones with alcohols, especially under metal-free conditions, with broad substrate scope. A possible mechanism is proposed on the basis of a series of control experiments and DMSO¹⁸ isotopic labelling experiments.

Original language	English
Pages (from-to)	98422-98426
Number of pages	5
Journal	RSC Advances
Volume	6
Issue number	100
DOIs	https://doi.org/10.1039/c6ra19485k
State	Published - 2016

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title = "Metal-free oxidative esterification of acetophenones with alcohols: A facile one-pot approach to α-ketoesters",

abstract = "A novel and efficient oxidative esterification method for the synthesis of α-ketoesters has been developed under mild and environmentally benign conditions, which is a facile one-pot approach to α-ketoesters from commercially available acetophenones with alcohols, especially under metal-free conditions, with broad substrate scope. A possible mechanism is proposed on the basis of a series of control experiments and DMSO18 isotopic labelling experiments.",

author = "Shiyu Guo and Zhongxue Dai and Zhao Yang and Ning Zhu and Li Wan and Xin Li and Chengkou Liu and Zheng Fang and Kai Guo",

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year = "2016",

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T1 - Metal-free oxidative esterification of acetophenones with alcohols

T2 - A facile one-pot approach to α-ketoesters

AU - Guo, Shiyu

AU - Dai, Zhongxue

AU - Yang, Zhao

AU - Zhu, Ning

AU - Wan, Li

AU - Li, Xin

AU - Liu, Chengkou

AU - Fang, Zheng

AU - Guo, Kai

PY - 2016

Y1 - 2016

N2 - A novel and efficient oxidative esterification method for the synthesis of α-ketoesters has been developed under mild and environmentally benign conditions, which is a facile one-pot approach to α-ketoesters from commercially available acetophenones with alcohols, especially under metal-free conditions, with broad substrate scope. A possible mechanism is proposed on the basis of a series of control experiments and DMSO18 isotopic labelling experiments.

AB - A novel and efficient oxidative esterification method for the synthesis of α-ketoesters has been developed under mild and environmentally benign conditions, which is a facile one-pot approach to α-ketoesters from commercially available acetophenones with alcohols, especially under metal-free conditions, with broad substrate scope. A possible mechanism is proposed on the basis of a series of control experiments and DMSO18 isotopic labelling experiments.

UR - http://www.scopus.com/inward/record.url?scp=84992179802&partnerID=8YFLogxK

U2 - 10.1039/c6ra19485k

DO - 10.1039/c6ra19485k

M3 - 文章

AN - SCOPUS:84992179802

SN - 2046-2069

VL - 6

SP - 98422

EP - 98426

JO - RSC Advances

JF - RSC Advances

IS - 100

ER -

Metal-free oxidative esterification of acetophenones with alcohols: A facile one-pot approach to α-ketoesters

Abstract

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