Microbial production of vitamin K2: current status and future prospects

Lujing Ren; Cheng Peng; Xuechao Hu; Yiwen Han; He Huang

doi:10.1016/j.biotechadv.2019.107453

Microbial production of vitamin K2: current status and future prospects

Lujing Ren, Cheng Peng, Xuechao Hu, Yiwen Han, He Huang

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

Vitamin K2, also called menaquinone, is an essential lipid-soluble vitamin that plays a critical role in blood clotting and prevention of osteoporosis. It has become a focus of research in recent years and has been widely used in the food and pharmaceutical industries. This review will briefly introduce the functions and applications of vitamin K2 first, after which the biosynthesis pathways and enzymes will be analyzed in-depth to highlight the bottlenecks facing the microbial vitamin K2 production on the industrial scale. Then, various strategies, including strain mutagenesis and genetic modification, different cultivation modes, fermentation and separation processes, will be summarized and discussed. The future prospects and perspectives of microbial menaquinone production will also be discussed finally.

Original language	English
Article number	107453
Journal	Biotechnology Advances
Volume	39
DOIs	https://doi.org/10.1016/j.biotechadv.2019.107453
State	Published - 1 Mar 2020

Keywords

Bacillus
Downstream processing
Menaquinone
Process engineering
Strain improvement
Vitamin K2

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10.1016/j.biotechadv.2019.107453

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title = "Microbial production of vitamin K2: current status and future prospects",

abstract = "Vitamin K2, also called menaquinone, is an essential lipid-soluble vitamin that plays a critical role in blood clotting and prevention of osteoporosis. It has become a focus of research in recent years and has been widely used in the food and pharmaceutical industries. This review will briefly introduce the functions and applications of vitamin K2 first, after which the biosynthesis pathways and enzymes will be analyzed in-depth to highlight the bottlenecks facing the microbial vitamin K2 production on the industrial scale. Then, various strategies, including strain mutagenesis and genetic modification, different cultivation modes, fermentation and separation processes, will be summarized and discussed. The future prospects and perspectives of microbial menaquinone production will also be discussed finally.",

keywords = "Bacillus, Downstream processing, Menaquinone, Process engineering, Strain improvement, Vitamin K2",

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T1 - Microbial production of vitamin K2

T2 - current status and future prospects

AU - Ren, Lujing

AU - Peng, Cheng

AU - Hu, Xuechao

AU - Han, Yiwen

AU - Huang, He

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Vitamin K2, also called menaquinone, is an essential lipid-soluble vitamin that plays a critical role in blood clotting and prevention of osteoporosis. It has become a focus of research in recent years and has been widely used in the food and pharmaceutical industries. This review will briefly introduce the functions and applications of vitamin K2 first, after which the biosynthesis pathways and enzymes will be analyzed in-depth to highlight the bottlenecks facing the microbial vitamin K2 production on the industrial scale. Then, various strategies, including strain mutagenesis and genetic modification, different cultivation modes, fermentation and separation processes, will be summarized and discussed. The future prospects and perspectives of microbial menaquinone production will also be discussed finally.

AB - Vitamin K2, also called menaquinone, is an essential lipid-soluble vitamin that plays a critical role in blood clotting and prevention of osteoporosis. It has become a focus of research in recent years and has been widely used in the food and pharmaceutical industries. This review will briefly introduce the functions and applications of vitamin K2 first, after which the biosynthesis pathways and enzymes will be analyzed in-depth to highlight the bottlenecks facing the microbial vitamin K2 production on the industrial scale. Then, various strategies, including strain mutagenesis and genetic modification, different cultivation modes, fermentation and separation processes, will be summarized and discussed. The future prospects and perspectives of microbial menaquinone production will also be discussed finally.

KW - Bacillus

KW - Downstream processing

KW - Menaquinone

KW - Process engineering

KW - Strain improvement

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M3 - 文献综述

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SN - 0734-9750

VL - 39

JO - Biotechnology Advances

JF - Biotechnology Advances

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Microbial production of vitamin K2: current status and future prospects

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Keywords

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