Nickel-Catalyzed Reductive Amidation of Aryl Sulfonium Salts with Isocyanates for Amide Synthesis via C−S Bond Activation

Xue Chen; Meng Ke Xu; Xuan Qi Zhang; Chengping Miao; Xue Qiang Chu; Weidong Rao; Hao Xu; Xiaocong Zhou; Zhi Liang Shen

doi:10.1002/adsc.202400424

Nickel-Catalyzed Reductive Amidation of Aryl Sulfonium Salts with Isocyanates for Amide Synthesis via C−S Bond Activation

Xue Chen, Meng Ke Xu, Xuan Qi Zhang, Chengping Miao, Xue Qiang Chu, Weidong Rao, Hao Xu, Xiaocong Zhou, Zhi Liang Shen

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A nickel-catalyzed reductive amidation of aryl sulfonium salts with isocyanates for amide synthesis via C−S bond cleavage was developed. The reactions proceeded smoothly at ambient temperature in the presence of nickel catalyst and manganese metal in DMF to give a variety of amides in moderate to good yields with wide functional group tolerance.

Original language	English
Pages (from-to)	3839-3844
Number of pages	6
Journal	Advanced Synthesis and Catalysis
Volume	366
Issue number	18
DOIs	https://doi.org/10.1002/adsc.202400424
State	Published - 17 Sep 2024

Keywords

C−S bond activation
amides
isocyanates
nickel catalysis
reductive amidation
sulfonium salts

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10.1002/adsc.202400424

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title = "Nickel-Catalyzed Reductive Amidation of Aryl Sulfonium Salts with Isocyanates for Amide Synthesis via C−S Bond Activation",

abstract = "A nickel-catalyzed reductive amidation of aryl sulfonium salts with isocyanates for amide synthesis via C−S bond cleavage was developed. The reactions proceeded smoothly at ambient temperature in the presence of nickel catalyst and manganese metal in DMF to give a variety of amides in moderate to good yields with wide functional group tolerance.",

keywords = "C−S bond activation, amides, isocyanates, nickel catalysis, reductive amidation, sulfonium salts",

author = "Xue Chen and Xu, {Meng Ke} and Zhang, {Xuan Qi} and Chengping Miao and Chu, {Xue Qiang} and Weidong Rao and Hao Xu and Xiaocong Zhou and Shen, {Zhi Liang}",

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doi = "10.1002/adsc.202400424",

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TY - JOUR

T1 - Nickel-Catalyzed Reductive Amidation of Aryl Sulfonium Salts with Isocyanates for Amide Synthesis via C−S Bond Activation

AU - Chen, Xue

AU - Xu, Meng Ke

AU - Zhang, Xuan Qi

AU - Miao, Chengping

AU - Chu, Xue Qiang

AU - Rao, Weidong

AU - Xu, Hao

AU - Zhou, Xiaocong

AU - Shen, Zhi Liang

PY - 2024/9/17

Y1 - 2024/9/17

N2 - A nickel-catalyzed reductive amidation of aryl sulfonium salts with isocyanates for amide synthesis via C−S bond cleavage was developed. The reactions proceeded smoothly at ambient temperature in the presence of nickel catalyst and manganese metal in DMF to give a variety of amides in moderate to good yields with wide functional group tolerance.

AB - A nickel-catalyzed reductive amidation of aryl sulfonium salts with isocyanates for amide synthesis via C−S bond cleavage was developed. The reactions proceeded smoothly at ambient temperature in the presence of nickel catalyst and manganese metal in DMF to give a variety of amides in moderate to good yields with wide functional group tolerance.

KW - C−S bond activation

KW - amides

KW - isocyanates

KW - nickel catalysis

KW - reductive amidation

KW - sulfonium salts

UR - http://www.scopus.com/inward/record.url?scp=85203148276&partnerID=8YFLogxK

U2 - 10.1002/adsc.202400424

DO - 10.1002/adsc.202400424

M3 - 文章

AN - SCOPUS:85203148276

SN - 1615-4150

VL - 366

SP - 3839

EP - 3844

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

IS - 18

ER -

Nickel-Catalyzed Reductive Amidation of Aryl Sulfonium Salts with Isocyanates for Amide Synthesis via C−S Bond Activation

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Keywords

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