Plasmonic bimetallic nanodisk arrays for DNA conformation sensing

Thanh Thi Van Nguyen; Xiaoji Xie; Jiahui Xu; Yiming Wu; Minghui Hong; Xiaogang Liu

doi:10.1039/c9nr06101k

Plasmonic bimetallic nanodisk arrays for DNA conformation sensing

Thanh Thi Van Nguyen, Xiaoji Xie, Jiahui Xu, Yiming Wu, Minghui Hong, Xiaogang Liu

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The integration of large-scale 2D bimetallic Ag/Au nanodisk arrays with gold nanoparticles is developed for sensing DNA conformation with the assistance of 3D finite-difference time-domain simulation. The optimized system comprising Ag/Au nanodisk arrays and gold nanoparticles offers a more than 6-fold enhancement in surface plasmon resonance shift, enabling the feasibility for sensitive DNA detection with a detection limit down to 100 femtomolar. Importantly, owing to the distance-dependent nature of the surface plasmon signal, sensitive differentiation of DNA conformations can be achieved with a conventional optical measurement. This platform could provide new exciting capabilities for a reliable, reproducible, and label-free assay analysis for investigating the conformations of DNA and other biological molecules.

Original language	English
Pages (from-to)	19291-19296
Number of pages	6
Journal	Nanoscale
Volume	11
Issue number	41
DOIs	https://doi.org/10.1039/c9nr06101k
State	Published - 7 Nov 2019
Externally published	Yes

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title = "Plasmonic bimetallic nanodisk arrays for DNA conformation sensing",

abstract = "The integration of large-scale 2D bimetallic Ag/Au nanodisk arrays with gold nanoparticles is developed for sensing DNA conformation with the assistance of 3D finite-difference time-domain simulation. The optimized system comprising Ag/Au nanodisk arrays and gold nanoparticles offers a more than 6-fold enhancement in surface plasmon resonance shift, enabling the feasibility for sensitive DNA detection with a detection limit down to 100 femtomolar. Importantly, owing to the distance-dependent nature of the surface plasmon signal, sensitive differentiation of DNA conformations can be achieved with a conventional optical measurement. This platform could provide new exciting capabilities for a reliable, reproducible, and label-free assay analysis for investigating the conformations of DNA and other biological molecules.",

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AU - Nguyen, Thanh Thi Van

AU - Xie, Xiaoji

AU - Xu, Jiahui

AU - Wu, Yiming

AU - Hong, Minghui

AU - Liu, Xiaogang

PY - 2019/11/7

Y1 - 2019/11/7

N2 - The integration of large-scale 2D bimetallic Ag/Au nanodisk arrays with gold nanoparticles is developed for sensing DNA conformation with the assistance of 3D finite-difference time-domain simulation. The optimized system comprising Ag/Au nanodisk arrays and gold nanoparticles offers a more than 6-fold enhancement in surface plasmon resonance shift, enabling the feasibility for sensitive DNA detection with a detection limit down to 100 femtomolar. Importantly, owing to the distance-dependent nature of the surface plasmon signal, sensitive differentiation of DNA conformations can be achieved with a conventional optical measurement. This platform could provide new exciting capabilities for a reliable, reproducible, and label-free assay analysis for investigating the conformations of DNA and other biological molecules.

AB - The integration of large-scale 2D bimetallic Ag/Au nanodisk arrays with gold nanoparticles is developed for sensing DNA conformation with the assistance of 3D finite-difference time-domain simulation. The optimized system comprising Ag/Au nanodisk arrays and gold nanoparticles offers a more than 6-fold enhancement in surface plasmon resonance shift, enabling the feasibility for sensitive DNA detection with a detection limit down to 100 femtomolar. Importantly, owing to the distance-dependent nature of the surface plasmon signal, sensitive differentiation of DNA conformations can be achieved with a conventional optical measurement. This platform could provide new exciting capabilities for a reliable, reproducible, and label-free assay analysis for investigating the conformations of DNA and other biological molecules.

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JO - Nanoscale

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Plasmonic bimetallic nanodisk arrays for DNA conformation sensing

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