Preparation and characterization of magnetic mesoporous bioactive glass/carbon composite scaffolds

Min Zhu, Jianhua Zhang, Yinghong Zhou, Yunfei Liu, Xing He, Cuilian Tao, Yufang Zhu

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25 Scopus citations

Abstract

The magnetic Fe-MBG/C composite scaffolds with enhanced mechanical strength and multifunctionality have been successfully prepared. The study showed that the Fe-MBG/C composite scaffolds with the porosity of ca. 80% had interconnected macropores (200-500 μm) and mesopores (3.7-4.4 nm) and significantly enhanced the compressive strength compared to the pure MBG scaffolds. Importantly, the Fe-MBG/C composite scaffolds exhibited good bioactivity and sustained drug release property. At the same time, the Fe-MBG/C composite scaffolds could generate heat to raise the temperature of surrounding environment in an alternating magnetic field due to their superparamagnetic behavior. Therefore, the magnetic Fe-MBG/C composite scaffolds could form a multifunctional platform with bone regeneration, magnetic hyperthermia, and local drug delivery and have more potential for use in the regeneration of the critical-sized bone defects caused by bone tumors.

Original languageEnglish
Article number893479
JournalJournal of Chemistry
DOIs
StatePublished - 2013

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