Preparation and pharmaceutical study of microemulsion gel system for transdermal delivery of celecoxib

Objective: To develop microemulsion-based organogels(MBGs) to enhance the in vitro transdermal penetration and bioavailability of celecoxib. Methods: Microemulsion was obtained based on the pseudo-ternary phase diagram. By using single-factor test, the formation of microemulsion was optimized. Pharmacokinetics of MBGs in experimental rabbits was studied in comparison with the marketed capsules. Results: The celecoxib microemulsion gel was composed of triacetin 6.7%, 21.5% Tween-80, 21.5% Transcutol-p, 50% water, 1.5% celecoxib, and 1% carbopol 940. Conclusion: The devoloped MBGs have improved bioavailability and may be a new delivery system for transdermal administration of celecoxib.