Programming therapeutic probiotics by self-tunable sense-and-respond genetic circuits

Yuxin Liu; Zhengming Zhu; Ling Jiang

doi:10.1016/j.tim.2023.08.001

Programming therapeutic probiotics by self-tunable sense-and-respond genetic circuits

Yuxin Liu, Zhengming Zhu, Ling Jiang

COLLEGE OF FOOD SCIENCE AND LIGHT INDUSTRY

Nanjing Tech University

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

Probiotics can be programmed to sense and respond to intracellular disease signals to deliver the desired therapeutic effectors. The sense-and-respond genetic circuits, especially self-tunable ones, hold promise in improving the precision, effectiveness, and intelligence of therapeutic activities. Here, we present notable advances in the creation of engineered probiotics that harbour sense-and-respond genetic circuits.

Original language	English
Pages (from-to)	1099-1101
Number of pages	3
Journal	Trends in Microbiology
Volume	31
Issue number	11
DOIs	https://doi.org/10.1016/j.tim.2023.08.001
State	Published - Nov 2023

Keywords

engineered probiotics
genetic circuits
sense and respond
synthetic biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tim.2023.08.001

Cite this

@article{5ab0b4ecab74458a891f9d075bc5194f,

title = "Programming therapeutic probiotics by self-tunable sense-and-respond genetic circuits",

abstract = "Probiotics can be programmed to sense and respond to intracellular disease signals to deliver the desired therapeutic effectors. The sense-and-respond genetic circuits, especially self-tunable ones, hold promise in improving the precision, effectiveness, and intelligence of therapeutic activities. Here, we present notable advances in the creation of engineered probiotics that harbour sense-and-respond genetic circuits.",

keywords = "engineered probiotics, genetic circuits, sense and respond, synthetic biology",

author = "Yuxin Liu and Zhengming Zhu and Ling Jiang",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = nov,

doi = "10.1016/j.tim.2023.08.001",

language = "英语",

volume = "31",

pages = "1099--1101",

journal = "Trends in Microbiology",

issn = "0966-842X",

publisher = "Elsevier Ltd",

number = "11",

}

TY - JOUR

T1 - Programming therapeutic probiotics by self-tunable sense-and-respond genetic circuits

AU - Liu, Yuxin

AU - Zhu, Zhengming

AU - Jiang, Ling

PY - 2023/11

Y1 - 2023/11

N2 - Probiotics can be programmed to sense and respond to intracellular disease signals to deliver the desired therapeutic effectors. The sense-and-respond genetic circuits, especially self-tunable ones, hold promise in improving the precision, effectiveness, and intelligence of therapeutic activities. Here, we present notable advances in the creation of engineered probiotics that harbour sense-and-respond genetic circuits.

AB - Probiotics can be programmed to sense and respond to intracellular disease signals to deliver the desired therapeutic effectors. The sense-and-respond genetic circuits, especially self-tunable ones, hold promise in improving the precision, effectiveness, and intelligence of therapeutic activities. Here, we present notable advances in the creation of engineered probiotics that harbour sense-and-respond genetic circuits.

KW - engineered probiotics

KW - genetic circuits

KW - sense and respond

KW - synthetic biology

UR - http://www.scopus.com/inward/record.url?scp=85168743000&partnerID=8YFLogxK

U2 - 10.1016/j.tim.2023.08.001

DO - 10.1016/j.tim.2023.08.001

M3 - 短篇评述

C2 - 37620240

AN - SCOPUS:85168743000

SN - 0966-842X

VL - 31

SP - 1099

EP - 1101

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 11

ER -

Programming therapeutic probiotics by self-tunable sense-and-respond genetic circuits

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this