Abstract
A transition metal-free radical process for the selective α,β-dehydrogenation of saturated amides under mild conditions is developed. Utilizing radical activation strategy, the challenging issue associated with the low α-acidity of amides is resolved. For the first time, α,β-unsaturated Weinreb amides and acrylamides could be efficiently prepared directly from corresponding saturated amides. Mechanistic studies confirm the radical nature of this transformation. Two gram scale α,β-dehydrogenation have also been performed to demonstrate the utility of this method.
Original language | English |
---|---|
Pages (from-to) | 8267-8274 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 84 |
Issue number | 12 |
DOIs | |
State | Published - 21 Jun 2019 |