Regioselective and Geometrically Controlled Heck 1,1-Diarylation of Unactivated Aliphatic Alkenes

Yao Zhao, Shuangqiang Wang, Huihui Shao, Xuyong Tan, Rizhi Chen, Teck Peng Loh, Jianrong Steve Zhou, Xiaojin Wu

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Pd-catalyzed double Heck reaction allows regioselective 1,1-diarylation of unactivated aliphatic alkenes. When two different aryl bromides are used, the second aryl rings are added trans to aliphatic chains in the main olefinic isomers, consistent with a mechanism of two consecutive Heck arylations at the terminal carbons.

Original languageEnglish
Pages (from-to)4258-4263
Number of pages6
JournalOrganic Letters
Volume25
Issue number23
DOIs
StatePublished - 16 Jun 2023

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