Regioselective iodoamination of terminal ynamides for the synthesis of α-amino-β,β-diiodo-enamides

Hai Huang; Luning Tang; Xiaobo Han; Guangke He; Yang Xi; Hongjun Zhu

doi:10.1039/c6cc00370b

Regioselective iodoamination of terminal ynamides for the synthesis of α-amino-β,β-diiodo-enamides

Hai Huang, Luning Tang, Xiaobo Han, Guangke He, Yang Xi, Hongjun Zhu

School of Chemistry and Moleculai Engineering

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A mild and efficient methodology involving the I₂/TBHP-mediated intermolecular iodoamination of ynamides with amines for the synthesis of α-amino-β,β-diiodo-enamides was developed. This reaction provides the first intermolecular iodoamination of terminal alkynes to diiodo-enamines and can be easily applied to a wide range of substrates.

Original language	English
Pages (from-to)	4321-4324
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	23
DOIs	https://doi.org/10.1039/c6cc00370b
State	Published - 2016

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title = "Regioselective iodoamination of terminal ynamides for the synthesis of α-amino-β,β-diiodo-enamides",

abstract = "A mild and efficient methodology involving the I2/TBHP-mediated intermolecular iodoamination of ynamides with amines for the synthesis of α-amino-β,β-diiodo-enamides was developed. This reaction provides the first intermolecular iodoamination of terminal alkynes to diiodo-enamines and can be easily applied to a wide range of substrates.",

author = "Hai Huang and Luning Tang and Xiaobo Han and Guangke He and Yang Xi and Hongjun Zhu",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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T1 - Regioselective iodoamination of terminal ynamides for the synthesis of α-amino-β,β-diiodo-enamides

AU - Huang, Hai

AU - Tang, Luning

AU - Han, Xiaobo

AU - He, Guangke

AU - Xi, Yang

AU - Zhu, Hongjun

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2016

Y1 - 2016

N2 - A mild and efficient methodology involving the I2/TBHP-mediated intermolecular iodoamination of ynamides with amines for the synthesis of α-amino-β,β-diiodo-enamides was developed. This reaction provides the first intermolecular iodoamination of terminal alkynes to diiodo-enamines and can be easily applied to a wide range of substrates.

AB - A mild and efficient methodology involving the I2/TBHP-mediated intermolecular iodoamination of ynamides with amines for the synthesis of α-amino-β,β-diiodo-enamides was developed. This reaction provides the first intermolecular iodoamination of terminal alkynes to diiodo-enamines and can be easily applied to a wide range of substrates.

UR - http://www.scopus.com/inward/record.url?scp=84960926042&partnerID=8YFLogxK

U2 - 10.1039/c6cc00370b

DO - 10.1039/c6cc00370b

M3 - 文章

C2 - 26916142

AN - SCOPUS:84960926042

SN - 1359-7345

VL - 52

SP - 4321

EP - 4324

JO - Chemical Communications

JF - Chemical Communications

IS - 23

ER -

Regioselective iodoamination of terminal ynamides for the synthesis of α-amino-β,β-diiodo-enamides

Abstract

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