Site-selective C(sp3)-H amination of thioamide with anthranils under Cp∗CoIII catalysis

Rui Hua Liu; Qi Chao Shan; Xu Hong Hu; Teck Peng Loh

doi:10.1039/c9cc01715a

Site-selective C(sp³)-H amination of thioamide with anthranils under Cp∗Co^III catalysis

Rui Hua Liu, Qi Chao Shan, Xu Hong Hu, Teck Peng Loh

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Synthetically versatile anthranils as a bifunctional amino source have been employed for the first time to enable direct amination on unactivated C(sp³)-H bonds of thioamides under Cp∗Co^III catalysis. The excellent site-selectivity on primary C(sp³)-H bonds is observed for a diverse array of thioamides with high functional group tolerance. Further applicability of the products is also highlighted through a series of interesting synthetic elaborations.

Original language	English
Pages (from-to)	5519-5522
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	38
DOIs	https://doi.org/10.1039/c9cc01715a
State	Published - 2019

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abstract = "Synthetically versatile anthranils as a bifunctional amino source have been employed for the first time to enable direct amination on unactivated C(sp3)-H bonds of thioamides under Cp∗CoIII catalysis. The excellent site-selectivity on primary C(sp3)-H bonds is observed for a diverse array of thioamides with high functional group tolerance. Further applicability of the products is also highlighted through a series of interesting synthetic elaborations.",

author = "Liu, {Rui Hua} and Shan, {Qi Chao} and Hu, {Xu Hong} and Loh, {Teck Peng}",

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AU - Liu, Rui Hua

AU - Shan, Qi Chao

AU - Hu, Xu Hong

AU - Loh, Teck Peng

N1 - Publisher Copyright: © The Royal Society of Chemistry 2019.

PY - 2019

Y1 - 2019

N2 - Synthetically versatile anthranils as a bifunctional amino source have been employed for the first time to enable direct amination on unactivated C(sp3)-H bonds of thioamides under Cp∗CoIII catalysis. The excellent site-selectivity on primary C(sp3)-H bonds is observed for a diverse array of thioamides with high functional group tolerance. Further applicability of the products is also highlighted through a series of interesting synthetic elaborations.

AB - Synthetically versatile anthranils as a bifunctional amino source have been employed for the first time to enable direct amination on unactivated C(sp3)-H bonds of thioamides under Cp∗CoIII catalysis. The excellent site-selectivity on primary C(sp3)-H bonds is observed for a diverse array of thioamides with high functional group tolerance. Further applicability of the products is also highlighted through a series of interesting synthetic elaborations.

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U2 - 10.1039/c9cc01715a

DO - 10.1039/c9cc01715a

M3 - 文章

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AN - SCOPUS:85065540002

SN - 1359-7345

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Site-selective C(sp³)-H amination of thioamide with anthranils under Cp∗Co^III catalysis

Abstract

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