Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

Yu Cai; Weili Si; Qianyun Tang; Pingping Liang; Chengwu Zhang; Peng Chen; Qi Zhang; Wei Huang; Xiaochen Dong

doi:10.1007/s12274-016-1332-2

Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

Yu Cai, Weili Si, Qianyun Tang, Pingping Liang, Chengwu Zhang, Peng Chen, Qi Zhang, Wei Huang, Xiaochen Dong

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Therapeutic nanoparticles (NPs) based on the donor–acceptor–donor structured small organic molecule diketopyrrolopyrrole (SDPP) were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation (660 nm, 1.0 W·cm^‒2), even at a low dose (0.16 mg·kg^‒1). [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	794-801
Number of pages	8
Journal	Nano Research
Volume	10
Issue number	3
DOIs	https://doi.org/10.1007/s12274-016-1332-2
State	Published - 1 Mar 2017

Keywords

diketopyrrolopyrrole
donor–acceptor–donor
photoacoustic imaging
photothermal therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12274-016-1332-2

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title = "Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy",

abstract = "Therapeutic nanoparticles (NPs) based on the donor–acceptor–donor structured small organic molecule diketopyrrolopyrrole (SDPP) were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation (660 nm, 1.0 W·cm‒2), even at a low dose (0.16 mg·kg‒1). [Figure not available: see fulltext.]",

keywords = "diketopyrrolopyrrole, donor–acceptor–donor, photoacoustic imaging, photothermal therapy",

author = "Yu Cai and Weili Si and Qianyun Tang and Pingping Liang and Chengwu Zhang and Peng Chen and Qi Zhang and Wei Huang and Xiaochen Dong",

note = "Publisher Copyright: {\textcopyright} 2016, Tsinghua University Press and Springer-Verlag Berlin Heidelberg.",

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doi = "10.1007/s12274-016-1332-2",

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T1 - Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

AU - Cai, Yu

AU - Si, Weili

AU - Tang, Qianyun

AU - Liang, Pingping

AU - Zhang, Chengwu

AU - Chen, Peng

AU - Zhang, Qi

AU - Huang, Wei

AU - Dong, Xiaochen

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Therapeutic nanoparticles (NPs) based on the donor–acceptor–donor structured small organic molecule diketopyrrolopyrrole (SDPP) were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation (660 nm, 1.0 W·cm‒2), even at a low dose (0.16 mg·kg‒1). [Figure not available: see fulltext.]

AB - Therapeutic nanoparticles (NPs) based on the donor–acceptor–donor structured small organic molecule diketopyrrolopyrrole (SDPP) were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation (660 nm, 1.0 W·cm‒2), even at a low dose (0.16 mg·kg‒1). [Figure not available: see fulltext.]

KW - diketopyrrolopyrrole

KW - donor–acceptor–donor

KW - photoacoustic imaging

KW - photothermal therapy

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U2 - 10.1007/s12274-016-1332-2

DO - 10.1007/s12274-016-1332-2

M3 - 文章

AN - SCOPUS:85006856372

SN - 1998-0124

VL - 10

SP - 794

EP - 801

JO - Nano Research

JF - Nano Research

IS - 3

ER -

Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

Abstract

Keywords

UN SDGs

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