Stereoselective synthesis of (R)-salmeterol via asymmetric cyanohydrin reaction

Wei Li, Hai Huang, Xiaodong Jin, Yujian Liu, Chaohang Xu, Hongjun Zhu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The authors described a short and highly enantioselective route to (R)-salmeterol involving asymmetric synthesis of cyanohydrin followed by nucleophilic substitution with 6-(4-phenylbutoxy) hexyl methanesulfonate.

Original languageEnglish
Pages (from-to)770-773
Number of pages4
JournalChemical Research in Chinese Universities
Volume30
Issue number5
DOIs
StatePublished - 27 Sep 2014

Keywords

  • Asymmetric synthesis
  • Catalysis
  • Cyanohydrin
  • Ethanolamine
  • Methanesulfonate

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