Study on synthesis of trandolapril

Zheng Fang; Zhao Yang; Ping Wei; Guo Guang Chen

Study on synthesis of trandolapril

Zheng Fang, Zhao Yang, Ping Wei, Guo Guang Chen

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

OBJECTIVE: To study the synthesis of trandolapril. METHODS: Trandolapril was synthesized from 1,1,3,3-tetra-methoxypropane by fractional hydrolysation, condensation, dehydration, Diels-Alder reaction, high pressure hydrogenation, cyclizatiohydrolysation, esterification, chiral resolution on silica gel column and hydrogenation with catalyst. RESULTS: Structures of key intermediates were confirmed by MS and ¹H-NMR data. The structure of trandolapril was identified by MS, IR, NMR and elemental analysis. CONCLUSION: Each step in this route was easily operated and the yield was higher than that reported. This method was successful without using expensive reagents and had the potential for industry.

Original language	English
Pages (from-to)	632-635
Number of pages	4
Journal	Chinese Pharmaceutical Journal
Volume	43
Issue number	8
State	Published - Apr 2008

Keywords

Chiral resolution
Synthesis
Trandolapril

Cite this

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title = "Study on synthesis of trandolapril",

abstract = "OBJECTIVE: To study the synthesis of trandolapril. METHODS: Trandolapril was synthesized from 1,1,3,3-tetra-methoxypropane by fractional hydrolysation, condensation, dehydration, Diels-Alder reaction, high pressure hydrogenation, cyclizatiohydrolysation, esterification, chiral resolution on silica gel column and hydrogenation with catalyst. RESULTS: Structures of key intermediates were confirmed by MS and 1H-NMR data. The structure of trandolapril was identified by MS, IR, NMR and elemental analysis. CONCLUSION: Each step in this route was easily operated and the yield was higher than that reported. This method was successful without using expensive reagents and had the potential for industry.",

keywords = "Chiral resolution, Synthesis, Trandolapril",

author = "Zheng Fang and Zhao Yang and Ping Wei and Chen, {Guo Guang}",

year = "2008",

month = apr,

language = "英语",

volume = "43",

pages = "632--635",

journal = "Chinese Pharmaceutical Journal",

issn = "1001-2494",

publisher = "Chinese Pharmaceutical Association",

number = "8",

}

TY - JOUR

T1 - Study on synthesis of trandolapril

AU - Fang, Zheng

AU - Yang, Zhao

AU - Wei, Ping

AU - Chen, Guo Guang

PY - 2008/4

Y1 - 2008/4

N2 - OBJECTIVE: To study the synthesis of trandolapril. METHODS: Trandolapril was synthesized from 1,1,3,3-tetra-methoxypropane by fractional hydrolysation, condensation, dehydration, Diels-Alder reaction, high pressure hydrogenation, cyclizatiohydrolysation, esterification, chiral resolution on silica gel column and hydrogenation with catalyst. RESULTS: Structures of key intermediates were confirmed by MS and 1H-NMR data. The structure of trandolapril was identified by MS, IR, NMR and elemental analysis. CONCLUSION: Each step in this route was easily operated and the yield was higher than that reported. This method was successful without using expensive reagents and had the potential for industry.

AB - OBJECTIVE: To study the synthesis of trandolapril. METHODS: Trandolapril was synthesized from 1,1,3,3-tetra-methoxypropane by fractional hydrolysation, condensation, dehydration, Diels-Alder reaction, high pressure hydrogenation, cyclizatiohydrolysation, esterification, chiral resolution on silica gel column and hydrogenation with catalyst. RESULTS: Structures of key intermediates were confirmed by MS and 1H-NMR data. The structure of trandolapril was identified by MS, IR, NMR and elemental analysis. CONCLUSION: Each step in this route was easily operated and the yield was higher than that reported. This method was successful without using expensive reagents and had the potential for industry.

KW - Chiral resolution

KW - Synthesis

KW - Trandolapril

UR - http://www.scopus.com/inward/record.url?scp=53049106953&partnerID=8YFLogxK

M3 - 文章

AN - SCOPUS:53049106953

SN - 1001-2494

VL - 43

SP - 632

EP - 635

JO - Chinese Pharmaceutical Journal

JF - Chinese Pharmaceutical Journal

IS - 8

ER -

Study on synthesis of trandolapril

Abstract

Keywords

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