TY - JOUR
T1 - Sustained-release ibuprofen prodrug particle
T2 - Emulsifier and initiator regulate the diameter and distribution
AU - Wang, Jia
AU - Zhang, Haixin
AU - Xu, Jie
AU - Qian, Hao
AU - Liu, Rui
AU - Xu, Zengchang
AU - Zhu, Hongjun
N1 - Publisher Copyright:
© 2020 Wiley Periodicals LLC
PY - 2021/2/5
Y1 - 2021/2/5
N2 - Polymers have played a vital part in the development of drug delivery systems (DDS). For DDS, having a controllable diameter and distribution are conducive to reproducibility of drug release behavior and efficacy. In this work, an ibuprofen prodrug (Ibu@PMMA) was synthesized by methyl methacrylate (MMA), ibuprofen monomer (Ibu@HEMA), and ethylene glycol dimethacrylate (EGDMA) via emulsion polymerization. The Ibu@PMMA exhibits spherical shapes, and its structural properties were characterized by NMR, FTIR, and SEM techniques. In addition, the hydrodynamic diameter and polydispersity index (PDI) of Ibu@PMMA were reduced by increasing the proportion of emulsifier. Meanwhile, by increasing the amount of initiator, the hydrodynamic diameter and PDI of Ibu@PMMA were decreased. Moreover, Ibu@PMMA exhibits good sustained-release ability in vitro, which could be used as a potential delivery system for anti-inflammatory agents.
AB - Polymers have played a vital part in the development of drug delivery systems (DDS). For DDS, having a controllable diameter and distribution are conducive to reproducibility of drug release behavior and efficacy. In this work, an ibuprofen prodrug (Ibu@PMMA) was synthesized by methyl methacrylate (MMA), ibuprofen monomer (Ibu@HEMA), and ethylene glycol dimethacrylate (EGDMA) via emulsion polymerization. The Ibu@PMMA exhibits spherical shapes, and its structural properties were characterized by NMR, FTIR, and SEM techniques. In addition, the hydrodynamic diameter and polydispersity index (PDI) of Ibu@PMMA were reduced by increasing the proportion of emulsifier. Meanwhile, by increasing the amount of initiator, the hydrodynamic diameter and PDI of Ibu@PMMA were decreased. Moreover, Ibu@PMMA exhibits good sustained-release ability in vitro, which could be used as a potential delivery system for anti-inflammatory agents.
KW - drug delivery systems
KW - emulsion polymerization
KW - nanostructured polymers
UR - http://www.scopus.com/inward/record.url?scp=85089182056&partnerID=8YFLogxK
U2 - 10.1002/app.49779
DO - 10.1002/app.49779
M3 - 文章
AN - SCOPUS:85089182056
SN - 0021-8995
VL - 138
JO - Journal of Applied Polymer Science
JF - Journal of Applied Polymer Science
IS - 5
M1 - 49779
ER -