Switchable C-H Functionalization of N-Tosyl Acrylamides with Acryloylsilanes

Shengjin Song, Ping Lu, Huan Liu, Sai Hu Cai, Chao Feng, Teck Peng Loh

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

A controllable Rh-catalyzed protocol to access alkylation and alkenylation-annulation of N-tosyl acrylamide with acryloyl silane is reported. In contrast to the directing group or catalyst-dependent divergent sp2 C-H alkylation/alkenylation, the intrinsic property of acryloylsilane allows the switchable reaction manifold, thereby affording either alkylation or annulation products with slight modification of the reaction conditions.

Original languageEnglish
Pages (from-to)2869-2872
Number of pages4
JournalOrganic Letters
Volume19
Issue number11
DOIs
StatePublished - 2 Jun 2017

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