Synthesis of N-(5-aryl-1,3,4-thiadiazol-2-yl)-2-(3-oxo-1,2-benzothiazol- 2(3H)-yl)acetamide derivatives promoted by carbodiimide condensation

Peng Yu, Jun Hu, Rong Wan, Xi Li, Shanlong Zheng, Yanhua Xu

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Novel N-(5-aryl-1,3,4-thiadiazol-2-yl)-2-(3-oxo-1,2-benzothiazol-2(3H)-yl) acetamide derivatives were prepared by 1-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride and N-hydroxybenzotrizole condensation catalysis in a convenient and fast method. These compounds were identified by IR, 1H NMR and elemental analyses and the intermediate compound 5-(2-chlorophenyl)-1,3,4-thiadiazol-2-amine was confirmed by single-crystal X-ray diffraction.

Original languageEnglish
Pages (from-to)347-350
Number of pages4
JournalJournal of Chemical Research
Volume38
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • 1-2-benzisothiazolin-3-one
  • 1-3-4-thiadiazole
  • Acetamide synthesis

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