TY - JOUR
T1 - Synthesis of New Ligand 1,2-Bis { di[(R,R) -1,3,2-oxzaphosphlidine] phosphino} ethane with C2 -symmetric Axis and Application in Rh-catalyzed Asymmetric Hydrogenation
AU - GONG, Da chun
AU - ZHOU, Hua
AU - WEI, Ping
AU - OUYANG, Ping kai
PY - 2007/9
Y1 - 2007/9
N2 - New ligand 1,2-bis {di[(R,R)-1,3,2-oxzaphosphlidine] phosphino} ethane [(R, R)-BDOPPEs 1, 2, 3 and 4] with C2-symmetric axis and bearing nitrogen and oxygen were synthesized from readily available optically active amino alcohols. Rh complexes with these ligands were highly enantioselective catalysts for asymmetric hydrogenation of N-benzoyldehydroamino acid derivatives and α-functionalized ketones in 99% e. e. and 98% e. e., respectively. This new class of (R,R)-BDOPPEs 1, 2, 3 and 4 gave much more effectivity and enantionselectivity than their corresponding non-C2-asymmetric aminophosphine phosphinite.
AB - New ligand 1,2-bis {di[(R,R)-1,3,2-oxzaphosphlidine] phosphino} ethane [(R, R)-BDOPPEs 1, 2, 3 and 4] with C2-symmetric axis and bearing nitrogen and oxygen were synthesized from readily available optically active amino alcohols. Rh complexes with these ligands were highly enantioselective catalysts for asymmetric hydrogenation of N-benzoyldehydroamino acid derivatives and α-functionalized ketones in 99% e. e. and 98% e. e., respectively. This new class of (R,R)-BDOPPEs 1, 2, 3 and 4 gave much more effectivity and enantionselectivity than their corresponding non-C2-asymmetric aminophosphine phosphinite.
KW - Asymmetric catalytic hydrogenation
KW - C-Symmetry
KW - Keywords (R,R)-BDOPPE
UR - http://www.scopus.com/inward/record.url?scp=67949110796&partnerID=8YFLogxK
U2 - 10.1016/S1005-9040(07)60119-6
DO - 10.1016/S1005-9040(07)60119-6
M3 - 文章
AN - SCOPUS:67949110796
SN - 1005-9040
VL - 23
SP - 544
EP - 548
JO - Chemical Research in Chinese Universities
JF - Chemical Research in Chinese Universities
IS - 5
ER -