The synthesis of UDP-selective fluorescent probe and its imaging application in living cells

Haiyan Chen; Srinivasulu Kambam; Xintong Ren; Cheng Zheng; Fang Wang; Yong Wang; Jun Yin; Jingjing Xie; Xiaoqiang Chen

doi:10.1016/j.bmcl.2014.11.057

The synthesis of UDP-selective fluorescent probe and its imaging application in living cells

Haiyan Chen, Srinivasulu Kambam, Xintong Ren, Cheng Zheng, Fang Wang, Yong Wang, Jun Yin, Jingjing Xie, Xiaoqiang Chen

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A perylene-based probe was developed for uridine diphosphate (UDP) sensing and cell imaging. The probe presented about 4-fold fluorescence enhancement in the presence or absence of 100 equiv UDP. The selectivity toward UDP over other phosphor-containing anions was observed. The selective UDP sensing was speculated to be related to the binding affinities of Zn²⁺ ions in sensor with the uridine and phosphate moieties of UDP. Furthermore, this probe was also applied to image of UDP in living cells.

Original language	English
Pages (from-to)	262-265
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2014.11.057
State	Published - 15 Jan 2015

Keywords

Cell imaging
Fluorescent probe
Perylene
UDP

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10.1016/j.bmcl.2014.11.057

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abstract = "A perylene-based probe was developed for uridine diphosphate (UDP) sensing and cell imaging. The probe presented about 4-fold fluorescence enhancement in the presence or absence of 100 equiv UDP. The selectivity toward UDP over other phosphor-containing anions was observed. The selective UDP sensing was speculated to be related to the binding affinities of Zn2+ ions in sensor with the uridine and phosphate moieties of UDP. Furthermore, this probe was also applied to image of UDP in living cells.",

keywords = "Cell imaging, Fluorescent probe, Perylene, UDP",

author = "Haiyan Chen and Srinivasulu Kambam and Xintong Ren and Cheng Zheng and Fang Wang and Yong Wang and Jun Yin and Jingjing Xie and Xiaoqiang Chen",

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AU - Chen, Haiyan

AU - Kambam, Srinivasulu

AU - Ren, Xintong

AU - Zheng, Cheng

AU - Wang, Fang

AU - Wang, Yong

AU - Yin, Jun

AU - Xie, Jingjing

AU - Chen, Xiaoqiang

PY - 2015/1/15

Y1 - 2015/1/15

N2 - A perylene-based probe was developed for uridine diphosphate (UDP) sensing and cell imaging. The probe presented about 4-fold fluorescence enhancement in the presence or absence of 100 equiv UDP. The selectivity toward UDP over other phosphor-containing anions was observed. The selective UDP sensing was speculated to be related to the binding affinities of Zn2+ ions in sensor with the uridine and phosphate moieties of UDP. Furthermore, this probe was also applied to image of UDP in living cells.

AB - A perylene-based probe was developed for uridine diphosphate (UDP) sensing and cell imaging. The probe presented about 4-fold fluorescence enhancement in the presence or absence of 100 equiv UDP. The selectivity toward UDP over other phosphor-containing anions was observed. The selective UDP sensing was speculated to be related to the binding affinities of Zn2+ ions in sensor with the uridine and phosphate moieties of UDP. Furthermore, this probe was also applied to image of UDP in living cells.

KW - Cell imaging

KW - Fluorescent probe

KW - Perylene

KW - UDP

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U2 - 10.1016/j.bmcl.2014.11.057

DO - 10.1016/j.bmcl.2014.11.057

M3 - 文章

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AN - SCOPUS:84922331892

SN - 0960-894X

VL - 25

SP - 262

EP - 265

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

The synthesis of UDP-selective fluorescent probe and its imaging application in living cells

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