Abstract
The theoretically determined molecular structures of N-protonated 1,3,4,6 methyl-substituted 4-(m-OH phenyl) piperidines are correlated to their experimentally derived analgesic activities. It is concluded that the orientation of the 3-methyl group plays a crucial role in determining agonism and antagonism.
| Original language | English |
|---|---|
| Pages (from-to) | 53-56 |
| Number of pages | 4 |
| Journal | NIDA research monograph |
| Volume | 75 |
| State | Published - 1986 |
| Externally published | Yes |