Two-stage flow synthesis of coumarin via O-acetylation of salicylaldehyde

Xin Li; Anbang Chen; Yangzhi Zhou; Lingling Huang; Zheng Fang; Haifeng Gan; Kai Guo

doi:10.1556/1846.2014.00043

Two-stage flow synthesis of coumarin via O-acetylation of salicylaldehyde

Xin Li, Anbang Chen, Yangzhi Zhou, Lingling Huang, Zheng Fang, Haifeng Gan, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Continuous-flow synthesis of coumarin was realized in a tandem microflow system containing two microreactors in this study. Generally, better reaction yield (91%) and less side reaction were obtained in the flow system compared with conventional method. Interestingly, different reaction pathways were observed between continuous-flow system and batch methods.

Original language	English
Pages (from-to)	82-86
Number of pages	5
Journal	Journal of Flow Chemistry
Volume	5
Issue number	2
DOIs	https://doi.org/10.1556/1846.2014.00043
State	Published - Jun 2015

Keywords

Continuous-flow approach
Coumarin

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10.1556/1846.2014.00043

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title = "Two-stage flow synthesis of coumarin via O-acetylation of salicylaldehyde",

abstract = "Continuous-flow synthesis of coumarin was realized in a tandem microflow system containing two microreactors in this study. Generally, better reaction yield (91%) and less side reaction were obtained in the flow system compared with conventional method. Interestingly, different reaction pathways were observed between continuous-flow system and batch methods.",

keywords = "Continuous-flow approach, Coumarin",

author = "Xin Li and Anbang Chen and Yangzhi Zhou and Lingling Huang and Zheng Fang and Haifeng Gan and Kai Guo",

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AU - Li, Xin

AU - Chen, Anbang

AU - Zhou, Yangzhi

AU - Huang, Lingling

AU - Fang, Zheng

AU - Gan, Haifeng

AU - Guo, Kai

PY - 2015/6

Y1 - 2015/6

N2 - Continuous-flow synthesis of coumarin was realized in a tandem microflow system containing two microreactors in this study. Generally, better reaction yield (91%) and less side reaction were obtained in the flow system compared with conventional method. Interestingly, different reaction pathways were observed between continuous-flow system and batch methods.

AB - Continuous-flow synthesis of coumarin was realized in a tandem microflow system containing two microreactors in this study. Generally, better reaction yield (91%) and less side reaction were obtained in the flow system compared with conventional method. Interestingly, different reaction pathways were observed between continuous-flow system and batch methods.

KW - Continuous-flow approach

KW - Coumarin

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U2 - 10.1556/1846.2014.00043

DO - 10.1556/1846.2014.00043

M3 - 文章

AN - SCOPUS:84971268460

SN - 2062-249X

VL - 5

SP - 82

EP - 86

JO - Journal of Flow Chemistry

JF - Journal of Flow Chemistry

IS - 2

ER -

Two-stage flow synthesis of coumarin via O-acetylation of salicylaldehyde

Abstract

Keywords

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