Viral capsid-like titania for selective enrichment of phosphorylated peptides

Panpan Cheng, Jianjian Lin, Xiaoyan Qiu, Wanna Zhang, Juan Cheng, Yong Wang, Nan Li, Jingying Yang, Haizhou Yu

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Viral capsid-like materials have been recognized as bionanotechnology platforms with great potential in controlled drug release, gene transfer and bioimaging. However, their functions still need to be optimized in aspects such as efficient drug transfer and selective targeting. Herein, we report a simple alternative strategy to fabricate viral capsid-like titania (VCL-TiO2) bearing ordered mesoporous channels and protrusions on its surface. The morphology of the synthesized titania materials matches nearly perfectly the outer surface of a real viral capsid. In particular, the robust VCL-TiO2 exhibits high porosity and a high degree of monodispersity in its particle size which makes it ideal for selectively and efficiently enriching phosphorylated peptides (PPs). Moreover, the microsized VCL-TiO2 could be easily collected and recycled through centrifugation.

Original languageEnglish
Pages (from-to)6759-6762
Number of pages4
JournalChemical Communications
Volume55
Issue number47
DOIs
StatePublished - 2019

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