Visible-light-induced regio- And stereoselective C(sp2)-H trifluoroethylation of enamides with 2,2,2-trifluoroethyl iodide

Kai Zhao, Ze Yu Zhang, Xian Lu Cui, Ying Xue Wang, Xian Dan Wu, Wei Ming Li, Jia Xu Wu, Li Li Zhao, Jing Yu Guo, Teck Peng Loh

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39 Scopus citations

Abstract

A photoredox-catalyzed regio- and stereoselective trifluoroethylation reaction of enamides using commercially available 2,2,2-trifluoroethyl iodide as trifluoroethylating agents has been developed, furnishing geometrically defined and synthetically and physiochemically pivotal β-trifluoroethylated enamides bearing a diverse range of functional groups.

Original languageEnglish
Pages (from-to)9029-9035
Number of pages7
JournalOrganic Letters
Volume22
Issue number22
DOIs
StatePublished - 20 Nov 2020

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