Zinc porphyrin-polydopamine core-shell nanostructures for enhanced photodynamic/photothermal cancer therapy

Changjin Ou, Yewei Zhang, Dong Pan, Kaikai Ding, Shichao Zhang, Wenjing Xu, Wenjun Wang, Weili Si, Zhou Yang, Xiaochen Dong

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Multimodal therapy, integrating two or more compositions with different functions into a nanoplatform, will generate the synergistic effects of the multi-components and effectively improve the tumor therapeutic efficacy. Herein, core-shell structured ZnP@PDA nanoparticles (NPs) were easily constructed via encapsulating the near-infrared (NIR) photosensitizer of zinc porphyrin nanoparticles (ZnP NPs) with polydopamine (PDA). The ZnP@PDA NPs displayed good biocompatibility and could effectively prevent aggregation after intravenous injection. Triggered by a NIR laser, the ZnP@PDA NPs exhibited excellent photodynamic performance. Furthermore, compared with PDA or ZnP NPs, the ZnP@PDA NPs showed improved photothermal performance with a high photothermal conversion efficiency (PCE) of 46.8% due to the triplet exciton quenching and fluorescence resonance energy transfer (FRET). In vitro and in vivo evaluations demonstrated that the ZnP@PDA NPs could directly target the tumor site via the enhanced permeability and retention (EPR) effect and exhibited strong phototoxicity and outstanding tumor phototherapeutic efficacy.

Original languageEnglish
Pages (from-to)1786-1792
Number of pages7
JournalMaterials Chemistry Frontiers
Volume3
Issue number9
DOIs
StatePublished - Sep 2019

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