Zinc porphyrin-polydopamine core-shell nanostructures for enhanced photodynamic/photothermal cancer therapy

Changjin Ou; Yewei Zhang; Dong Pan; Kaikai Ding; Shichao Zhang; Wenjing Xu; Wenjun Wang; Weili Si; Zhou Yang; Xiaochen Dong

doi:10.1039/c9qm00197b

Zinc porphyrin-polydopamine core-shell nanostructures for enhanced photodynamic/photothermal cancer therapy

Changjin Ou, Yewei Zhang, Dong Pan, Kaikai Ding, Shichao Zhang, Wenjing Xu, Wenjun Wang, Weili Si, Zhou Yang, Xiaochen Dong

SCHOOL OF FLEXIBLE ELECTRONICS(FUTURE TECHNOLOGIES)|INSTITUTE OF ADVANCED MATERIALS(IAM)

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Multimodal therapy, integrating two or more compositions with different functions into a nanoplatform, will generate the synergistic effects of the multi-components and effectively improve the tumor therapeutic efficacy. Herein, core-shell structured ZnP@PDA nanoparticles (NPs) were easily constructed via encapsulating the near-infrared (NIR) photosensitizer of zinc porphyrin nanoparticles (ZnP NPs) with polydopamine (PDA). The ZnP@PDA NPs displayed good biocompatibility and could effectively prevent aggregation after intravenous injection. Triggered by a NIR laser, the ZnP@PDA NPs exhibited excellent photodynamic performance. Furthermore, compared with PDA or ZnP NPs, the ZnP@PDA NPs showed improved photothermal performance with a high photothermal conversion efficiency (PCE) of 46.8% due to the triplet exciton quenching and fluorescence resonance energy transfer (FRET). In vitro and in vivo evaluations demonstrated that the ZnP@PDA NPs could directly target the tumor site via the enhanced permeability and retention (EPR) effect and exhibited strong phototoxicity and outstanding tumor phototherapeutic efficacy.

Original language	English
Pages (from-to)	1786-1792
Number of pages	7
Journal	Materials Chemistry Frontiers
Volume	3
Issue number	9
DOIs	https://doi.org/10.1039/c9qm00197b
State	Published - Sep 2019

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title = "Zinc porphyrin-polydopamine core-shell nanostructures for enhanced photodynamic/photothermal cancer therapy",

abstract = "Multimodal therapy, integrating two or more compositions with different functions into a nanoplatform, will generate the synergistic effects of the multi-components and effectively improve the tumor therapeutic efficacy. Herein, core-shell structured ZnP@PDA nanoparticles (NPs) were easily constructed via encapsulating the near-infrared (NIR) photosensitizer of zinc porphyrin nanoparticles (ZnP NPs) with polydopamine (PDA). The ZnP@PDA NPs displayed good biocompatibility and could effectively prevent aggregation after intravenous injection. Triggered by a NIR laser, the ZnP@PDA NPs exhibited excellent photodynamic performance. Furthermore, compared with PDA or ZnP NPs, the ZnP@PDA NPs showed improved photothermal performance with a high photothermal conversion efficiency (PCE) of 46.8% due to the triplet exciton quenching and fluorescence resonance energy transfer (FRET). In vitro and in vivo evaluations demonstrated that the ZnP@PDA NPs could directly target the tumor site via the enhanced permeability and retention (EPR) effect and exhibited strong phototoxicity and outstanding tumor phototherapeutic efficacy.",

author = "Changjin Ou and Yewei Zhang and Dong Pan and Kaikai Ding and Shichao Zhang and Wenjing Xu and Wenjun Wang and Weili Si and Zhou Yang and Xiaochen Dong",

note = "Publisher Copyright: {\textcopyright} 2019 the Partner Organisations.",

year = "2019",

month = sep,

doi = "10.1039/c9qm00197b",

language = "英语",

volume = "3",

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TY - JOUR

T1 - Zinc porphyrin-polydopamine core-shell nanostructures for enhanced photodynamic/photothermal cancer therapy

AU - Ou, Changjin

AU - Zhang, Yewei

AU - Pan, Dong

AU - Ding, Kaikai

AU - Zhang, Shichao

AU - Xu, Wenjing

AU - Wang, Wenjun

AU - Si, Weili

AU - Yang, Zhou

AU - Dong, Xiaochen

PY - 2019/9

Y1 - 2019/9

N2 - Multimodal therapy, integrating two or more compositions with different functions into a nanoplatform, will generate the synergistic effects of the multi-components and effectively improve the tumor therapeutic efficacy. Herein, core-shell structured ZnP@PDA nanoparticles (NPs) were easily constructed via encapsulating the near-infrared (NIR) photosensitizer of zinc porphyrin nanoparticles (ZnP NPs) with polydopamine (PDA). The ZnP@PDA NPs displayed good biocompatibility and could effectively prevent aggregation after intravenous injection. Triggered by a NIR laser, the ZnP@PDA NPs exhibited excellent photodynamic performance. Furthermore, compared with PDA or ZnP NPs, the ZnP@PDA NPs showed improved photothermal performance with a high photothermal conversion efficiency (PCE) of 46.8% due to the triplet exciton quenching and fluorescence resonance energy transfer (FRET). In vitro and in vivo evaluations demonstrated that the ZnP@PDA NPs could directly target the tumor site via the enhanced permeability and retention (EPR) effect and exhibited strong phototoxicity and outstanding tumor phototherapeutic efficacy.

AB - Multimodal therapy, integrating two or more compositions with different functions into a nanoplatform, will generate the synergistic effects of the multi-components and effectively improve the tumor therapeutic efficacy. Herein, core-shell structured ZnP@PDA nanoparticles (NPs) were easily constructed via encapsulating the near-infrared (NIR) photosensitizer of zinc porphyrin nanoparticles (ZnP NPs) with polydopamine (PDA). The ZnP@PDA NPs displayed good biocompatibility and could effectively prevent aggregation after intravenous injection. Triggered by a NIR laser, the ZnP@PDA NPs exhibited excellent photodynamic performance. Furthermore, compared with PDA or ZnP NPs, the ZnP@PDA NPs showed improved photothermal performance with a high photothermal conversion efficiency (PCE) of 46.8% due to the triplet exciton quenching and fluorescence resonance energy transfer (FRET). In vitro and in vivo evaluations demonstrated that the ZnP@PDA NPs could directly target the tumor site via the enhanced permeability and retention (EPR) effect and exhibited strong phototoxicity and outstanding tumor phototherapeutic efficacy.

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U2 - 10.1039/c9qm00197b

DO - 10.1039/c9qm00197b

M3 - 文章

AN - SCOPUS:85071161802

SN - 2052-1537

VL - 3

SP - 1786

EP - 1792

JO - Materials Chemistry Frontiers

JF - Materials Chemistry Frontiers

IS - 9

ER -

Zinc porphyrin-polydopamine core-shell nanostructures for enhanced photodynamic/photothermal cancer therapy

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