α-Nucleophilic Addition to α,β-Unsaturated Carbonyl Compounds via Photocatalytically Generated α-Carbonyl Carbocations

Chong Jin Zhang, Yu Sun, Jie Gong, Hao Zhang, Zhen Zhen Liu, Fang Wang, Jin Xiang Chen, Jian Ping Qu, Yan Biao Kang

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2 引用 (Scopus)

摘要

We report the photocatalytic oxidation of α-carbonyl radicals of amides or esters to the corresponding α-carbonyl carbocations through super photoreductant CBZ6 induced redox-neutral photocatalysis. The α-carbonyl radicals are formed by the β-addition of alkyl radicals generated in situ by the photocatalytic fragmentation of N-hydroxyphthalimide esters to the α,β-unsaturated amides and esters. This method enables the α-nucleophilic addition of hydroxyl or alkoxyl radicals to amides and esters without any prefunctionalization.

源语言英语
文章编号e202415496
期刊Angewandte Chemie - International Edition
64
3
DOI
出版状态已出版 - 15 1月 2025

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