A practical and efficient method for late-stage deuteration of terminal alkynes with silver salt as catalyst

Ding Chuan Wu, Jing Wen Bai, Lei Guo, Guang Qi Hu, Kai Hui Liu, Fei Fei Sheng, Hong Hai Zhang, Zheng Yi Sun, Kang Shen, Xiang Liu

科研成果: 期刊稿件文章同行评审

14 引用 (Scopus)

摘要

A practical and efficient H/D exchange method for selective deuteration of terminal alkynes was disclosed. The reaction was simply performed with CF3COOAg as catalyst at room temperature, affording products with high level of deuterium incorporation. The excellent site-selectivity and promising functional group tolerance of this protocol enabled deuteration of pharmaceuticals and nature product derivatives.

源语言英语
文章编号152807
期刊Tetrahedron Letters
66
DOI
出版状态已出版 - 2 3月 2021

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