Allylation of Lactol in Water

Mengxue Zheng; Wenxiu Gao; Lei Zhang; Kaiyu Yan; Zhenguo Zhang; Peizhong Xie; Teck Peng Loh

doi:10.1021/acs.orglett.4c04189

Allylation of Lactol in Water

Mengxue Zheng, Wenxiu Gao, Lei Zhang, Kaiyu Yan, Zhenguo Zhang, Peizhong Xie, Teck Peng Loh

化学与分子工程学院

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3H)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.

源语言	英语
页（从-至）	10201-10206
页数	6
期刊	Organic Letters
卷	26
期	47
DOI	https://doi.org/10.1021/acs.orglett.4c04189
出版状态	已出版 - 29 11月 2024

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author = "Mengxue Zheng and Wenxiu Gao and Lei Zhang and Kaiyu Yan and Zhenguo Zhang and Peizhong Xie and Loh, {Teck Peng}",

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AU - Zheng, Mengxue

AU - Gao, Wenxiu

AU - Zhang, Lei

AU - Yan, Kaiyu

AU - Zhang, Zhenguo

AU - Xie, Peizhong

AU - Loh, Teck Peng

PY - 2024/11/29

Y1 - 2024/11/29

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AB - We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3H)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.

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JO - Organic Letters

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Allylation of Lactol in Water

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