Bioinspired 3D-Printed MXene and Spidroin-Based Near-Infrared Light-Responsive Microneedle Scaffolds for Efficient Wound Management

Yun Shao, Kaiyi Dong, Xinyu Lu, Bingbing Gao, Bingfang He

科研成果: 期刊稿件文章同行评审

58 引用 (Scopus)

摘要

Biomedical dressings have been comprehensively explored for wound healing; however, the complicated manufacturing process and mono-function of the dressing remain critical challenges for further applications. Here, a versatile extrusion three-dimensional (3D) printing strategy to prepare MXene and spidroin-incorporated microneedle scaffolds with photothermal responsive and self-healing properties for promoting wound healing is proposed. Inspired by the cactus, the microneedle scaffold is composed of a top porous scaffold, and microneedles whose inverse opal (IO) photonic crystal (PC) structure and the ample space between the scaffold gaps endow the microneedle scaffold with high drug-carrying capacity. Furthermore, the excellent electrical and photothermal properties of MXene allow the microneedle scaffold to perform sensitive wound movement monitoring and controlled drug release under near-infrared irradiation. Moreover, the extensive hydrogen bonding and Schiff base between the spidroin, polyurethane (PU), and aloe vera gel (avGel) molecules conferred high self-healing and mechanical performance to the microneedle scaffold. In vivo experiments with rat models of wounds have shown that drug-laden microneedle scaffolds under near-infrared (NIR) light can promote the recovery of full-skin wounds. These unique characteristics suggest that 3D-printed multifunctional microneedle scaffolds show great potential for applications in facilitating wound healing and will find widespread applications in wound management.

源语言英语
页(从-至)56525-56534
页数10
期刊ACS Applied Materials and Interfaces
14
51
DOI
出版状态已出版 - 2022

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