Catalytic Dual 1,1-H-Abstraction/Insertion for Domino Spirocyclizations

Jiang Kai Qiu; Bo Jiang; Yi Long Zhu; Wen Juan Hao; De Cai Wang; Jun Sun; Ping Wei; Shu Jiang Tu; Guigen Li

doi:10.1021/jacs.5b05735

Catalytic Dual 1,1-H-Abstraction/Insertion for Domino Spirocyclizations

Jiang Kai Qiu, Bo Jiang, Yi Long Zhu, Wen Juan Hao, De Cai Wang, Jun Sun, Ping Wei, Shu Jiang Tu, Guigen Li

科研成果: 期刊稿件 › 文章 › 同行评审

213 引用（Scopus）

摘要

A catalytic domino spirocyclization of 1,7-enynes with simple cycloalkanes and cyclo-1,3-dicarbonyls has been established via multiple C-C bond formations from alkynyl/alkenyl functions and dual α,α-C(sp³)-H abstraction/insertion. The reaction involves addition, 6-exo-dig cyclization and radical coupling sequences under convenient catalytic conditions and provides a concise access to spiro cyclopenta[c]quinolines in good to excellent yields.

源语言	英语
页（从-至）	8928-8931
页数	4
期刊	Journal of the American Chemical Society
卷	137
期	28
DOI	https://doi.org/10.1021/jacs.5b05735
出版状态	已出版 - 22 7月 2015

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abstract = "A catalytic domino spirocyclization of 1,7-enynes with simple cycloalkanes and cyclo-1,3-dicarbonyls has been established via multiple C-C bond formations from alkynyl/alkenyl functions and dual α,α-C(sp3)-H abstraction/insertion. The reaction involves addition, 6-exo-dig cyclization and radical coupling sequences under convenient catalytic conditions and provides a concise access to spiro cyclopenta[c]quinolines in good to excellent yields.",

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AU - Qiu, Jiang Kai

AU - Jiang, Bo

AU - Zhu, Yi Long

AU - Hao, Wen Juan

AU - Wang, De Cai

AU - Sun, Jun

AU - Wei, Ping

AU - Tu, Shu Jiang

AU - Li, Guigen

PY - 2015/7/22

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N2 - A catalytic domino spirocyclization of 1,7-enynes with simple cycloalkanes and cyclo-1,3-dicarbonyls has been established via multiple C-C bond formations from alkynyl/alkenyl functions and dual α,α-C(sp3)-H abstraction/insertion. The reaction involves addition, 6-exo-dig cyclization and radical coupling sequences under convenient catalytic conditions and provides a concise access to spiro cyclopenta[c]quinolines in good to excellent yields.

AB - A catalytic domino spirocyclization of 1,7-enynes with simple cycloalkanes and cyclo-1,3-dicarbonyls has been established via multiple C-C bond formations from alkynyl/alkenyl functions and dual α,α-C(sp3)-H abstraction/insertion. The reaction involves addition, 6-exo-dig cyclization and radical coupling sequences under convenient catalytic conditions and provides a concise access to spiro cyclopenta[c]quinolines in good to excellent yields.

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M3 - 文章

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

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Catalytic Dual 1,1-H-Abstraction/Insertion for Domino Spirocyclizations

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