摘要
In this article, a novel zwitterionic conjugated polyelectrolyte containing tetraphenylethene unit was synthesized via Pd-catalyzed Sonogashira reaction. The resulting polymer (P2), which exhibited typical aggregation-induced emission (AIE) properties, was weakly fluorescent in dilute DMSO solution and showed bright fluorescence emissions when aggregated in DMSO/water mixtures or fabricated into conjugated polymer nanoparticles (CPNs). The nanoparticles from P2 could be prepared by reprecipitation method with an average diameter around 23 nm. Notably, the cell-staining efficiencies of lipid-P2 nanoparticles could be enhanced with lipid encapsulation and these nanoparticles were endocytosed via caveolae-mediated and clathrin-mediated endocytosis pathways. Furthermore, the lipid-P2 nanoparticles with low cytotoxicity, high photostability and efficient cell staining ability could be employed for in vitro detection of Fe3+ ions in A549 cells.
源语言 | 英语 |
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页(从-至) | 1686-1693 |
页数 | 8 |
期刊 | Journal of Polymer Science, Part A: Polymer Chemistry |
卷 | 54 |
期 | 12 |
DOI | |
出版状态 | 已出版 - 15 6月 2016 |
已对外发布 | 是 |