Conjugated polymer nanoparticles with aggregation induced emission characteristics for intracellular Fe3+ sensing

Dongliang Yang, Fei Li, Zhimin Luo, Biqing Bao, Yanling Hu, Lixing Weng, Yixiang Cheng, Lianhui Wang

科研成果: 期刊稿件文章同行评审

39 引用 (Scopus)

摘要

In this article, a novel zwitterionic conjugated polyelectrolyte containing tetraphenylethene unit was synthesized via Pd-catalyzed Sonogashira reaction. The resulting polymer (P2), which exhibited typical aggregation-induced emission (AIE) properties, was weakly fluorescent in dilute DMSO solution and showed bright fluorescence emissions when aggregated in DMSO/water mixtures or fabricated into conjugated polymer nanoparticles (CPNs). The nanoparticles from P2 could be prepared by reprecipitation method with an average diameter around 23 nm. Notably, the cell-staining efficiencies of lipid-P2 nanoparticles could be enhanced with lipid encapsulation and these nanoparticles were endocytosed via caveolae-mediated and clathrin-mediated endocytosis pathways. Furthermore, the lipid-P2 nanoparticles with low cytotoxicity, high photostability and efficient cell staining ability could be employed for in vitro detection of Fe3+ ions in A549 cells.

源语言英语
页(从-至)1686-1693
页数8
期刊Journal of Polymer Science, Part A: Polymer Chemistry
54
12
DOI
出版状态已出版 - 15 6月 2016
已对外发布

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