Copper-catalyzed trifluoromethylation of styrene derivatives with CF3SO2Na

Liu Hai Wu; Kai Zhao; Zhi Liang Shen; Teck Peng Loh

doi:10.1039/c7qo00416h

Copper-catalyzed trifluoromethylation of styrene derivatives with CF₃SO₂Na

Liu Hai Wu, Kai Zhao, Zhi Liang Shen, Teck Peng Loh

化学与分子工程学院

Nanyang Technological University

科研成果: 期刊稿件 › 文章 › 同行评审

48 引用（Scopus）

摘要

An efficient copper(i)-catalyzed trifluoromethylation of styrene derivatives using CF₃SO₂Na as a trifluoromethylating source in the presence of ^tBuOO^tBu has been developed. Mechanistic studies show that the reaction likely proceeds via a radical pathway, providing a general and straightforward access to trifluoromethylated styrene derivatives. Advantageously, excellent stereoselectivity is obtained with styrene derivatives in this transformation.

源语言	英语
页（从-至）	1872-1875
页数	4
期刊	Organic Chemistry Frontiers
卷	4
期	9
DOI	https://doi.org/10.1039/c7qo00416h
出版状态	已出版 - 9月 2017

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abstract = "An efficient copper(i)-catalyzed trifluoromethylation of styrene derivatives using CF3SO2Na as a trifluoromethylating source in the presence of tBuOOtBu has been developed. Mechanistic studies show that the reaction likely proceeds via a radical pathway, providing a general and straightforward access to trifluoromethylated styrene derivatives. Advantageously, excellent stereoselectivity is obtained with styrene derivatives in this transformation.",

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AB - An efficient copper(i)-catalyzed trifluoromethylation of styrene derivatives using CF3SO2Na as a trifluoromethylating source in the presence of tBuOOtBu has been developed. Mechanistic studies show that the reaction likely proceeds via a radical pathway, providing a general and straightforward access to trifluoromethylated styrene derivatives. Advantageously, excellent stereoselectivity is obtained with styrene derivatives in this transformation.

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Copper-catalyzed trifluoromethylation of styrene derivatives with CF3SO2Na

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Copper-catalyzed trifluoromethylation of styrene derivatives with CF₃SO₂Na